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@ARTICLE{Selvi:301370,
      author       = {S. Selvi and C. M. Real and M. Gentiluomo and K. Balounova
                      and K. Vokacova and A. Cumova and B. Mohlenikova-Duchonova
                      and C. Rizzato and E. Halasova and L. Vodickova and B.
                      Smolkova and K. Hemminki$^*$ and D. Campa and P. Vodicka},
      title        = {{G}enomic instability, {DNA} damage response and telomere
                      homeostasis in pancreatic cancer.},
      journal      = {Seminars in cancer biology},
      volume       = {113},
      issn         = {1044-579X},
      address      = {London},
      publisher    = {Academic Press},
      reportid     = {DKFZ-2025-01008},
      pages        = {59 - 73},
      year         = {2025},
      abstract     = {Pancreatic cancer (PC) is becoming one of the most serious
                      health problems at present, but its causes and risk factors
                      are still unclear. One of the drivers in pancreatic
                      carcinogenesis is altered genomic (DNA) integrity with
                      subsequent genomic instability in cancer cells. The latter
                      comprises a) DNA damage response and DNA repair mechanisms,
                      b) DNA replication and mitosis, c) epigenetic regulation,
                      and d) telomere maintenance. In our review we addressed the
                      above aspects in relation to the most abundant and severe
                      form of PC, pancreatic ductal adenocarcinoma (PDAC). In
                      summary, the interactions between the DNA damage response,
                      telomere homeostasis and mitotic regulation are not
                      comprehensively understood at present, including the
                      epigenetic factors entering the trait of genomic stability
                      maintenance. In addition, the complexity of telomere
                      homeostasis in relation to PDAC risk, prognosis and
                      prediction also warrants further investigations.},
      subtyp        = {Review Article},
      keywords     = {DNA damage (Other) / DNA repair (Other) / Epigenetic
                      regulation of genome integrity (Other) / Mitotic regulation
                      (Other) / Pancreatic Cancer (Other) / Telomere homeostasis
                      (Other)},
      cin          = {Z999},
      ddc          = {610},
      cid          = {I:(DE-He78)Z999-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40378535},
      doi          = {10.1016/j.semcancer.2025.05.005},
      url          = {https://inrepo02.dkfz.de/record/301370},
}