Home > Publications database > Epstein-Barr virus induces aberrant B cell migration and diapedesis via FAK-dependent chemotaxis pathways. > print

001     301495
005     20250525020811.0
024 7 _ |a 10.1038/s41467-025-59813-z
|2 doi
024 7 _ |a pmid:40389409
|2 pmid
024 7 _ |a altmetric:177228021
|2 altmetric
037 _ _ |a DKFZ-2025-01037
041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Delecluse, Susanne
|0 P:(DE-He78)3877ae274d0271d6bf311bb46539f013
|b 0
|e First author
|u dkfz
245 _ _ |a Epstein-Barr virus induces aberrant B cell migration and diapedesis via FAK-dependent chemotaxis pathways.
260 _ _ |a [London]
|c 2025
|b Springer Nature
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1747749565_3490
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
500 _ _ |a #EA:D400#LA:D400#
520 _ _ |a Infection with the Epstein-Barr virus (EBV) is a major risk factor for the development of cancer and autoimmune disorders. The virus enters the body in the pharynx, but EBV causes disease in distant organs, including the gut and the brain. Here we show, using in vitro culture and mouse infection models, that EBV-infected B cells display features of homing cells. Infected B cells undergo migration following paracrine CCL4 release and CCR1 induction, while CCR1 deficiency inhibits migration and, unexpectedly, proliferation of infected B cells. Furthermore, migrating EBV-infected B cells undergo CCL4-dependent diapedesis, induce ICAM-1 on endothelial cells, and disrupt the integrity of endothelial barriers. Both migration and diapedesis are regulated by FAK, with FAK inhibition blocking growth and survival of EBV-transformed B cells, as well as their spreading to spleen and brain in an animal model in vivo. Moreover, IL-10 secreted by EBV-infected B cells attracts and facilitates diapedesis of EBV-negative CD52highCD11c+ B cells, which have reported autoimmune properties. Our results thus provide mechanistic insight on EBV-induced B cell dysregulation, and also hint curbing migration as a potential target for reducing the pathogenicity of EBV-infected B cells.
536 _ _ |a 314 - Immunologie und Krebs (POF4-314)
|0 G:(DE-HGF)POF4-314
|c POF4-314
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
650 _ 7 |a Interleukin-10
|0 130068-27-8
|2 NLM Chemicals
650 _ 7 |a Receptors, CCR1
|2 NLM Chemicals
650 _ 7 |a Intercellular Adhesion Molecule-1
|0 126547-89-5
|2 NLM Chemicals
650 _ 7 |a Focal Adhesion Kinase 1
|0 EC 2.7.10.2
|2 NLM Chemicals
650 _ 7 |a Ptk2 protein, mouse
|0 EC 2.7.10.2
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a B-Lymphocytes: virology
|2 MeSH
650 _ 2 |a B-Lymphocytes: immunology
|2 MeSH
650 _ 2 |a B-Lymphocytes: metabolism
|2 MeSH
650 _ 2 |a Herpesvirus 4, Human: physiology
|2 MeSH
650 _ 2 |a Herpesvirus 4, Human: immunology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Chemotaxis
|2 MeSH
650 _ 2 |a Epstein-Barr Virus Infections: immunology
|2 MeSH
650 _ 2 |a Epstein-Barr Virus Infections: virology
|2 MeSH
650 _ 2 |a Epstein-Barr Virus Infections: pathology
|2 MeSH
650 _ 2 |a Epstein-Barr Virus Infections: metabolism
|2 MeSH
650 _ 2 |a Interleukin-10: metabolism
|2 MeSH
650 _ 2 |a Cell Movement
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Receptors, CCR1: metabolism
|2 MeSH
650 _ 2 |a Receptors, CCR1: genetics
|2 MeSH
650 _ 2 |a Intercellular Adhesion Molecule-1: metabolism
|2 MeSH
650 _ 2 |a Focal Adhesion Kinase 1: metabolism
|2 MeSH
650 _ 2 |a Endothelial Cells: metabolism
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
700 1 _ |a Baccianti, Francesco
|0 P:(DE-He78)0179ab69c93d0c5110458003dbc8af0c
|b 1
|u dkfz
700 1 _ |a Zala, Manon
|b 2
700 1 _ |a Steffens, Alina
|0 P:(DE-He78)704f69971aa28ce8ceb62c6118120ee2
|b 3
700 1 _ |a Drenda, Carolin
|0 P:(DE-He78)07729a8a27f6637e3d284a1441a2cfb7
|b 4
700 1 _ |a Judt, Daniel
|0 P:(DE-He78)500ea2412dae05bdfe615df3d9bc2470
|b 5
700 1 _ |a Holland-Letz, Tim
|0 P:(DE-He78)457c042884c901eb0a02c18bb1d30103
|b 6
|u dkfz
700 1 _ |a Poirey, Remy
|0 P:(DE-He78)27152949302e3bd0d681a6f0548912b9
|b 7
|u dkfz
700 1 _ |a Sujobert, Pierre
|0 0000-0003-1724-4792
|b 8
700 1 _ |a Delecluse, Henri-Jacques
|0 P:(DE-He78)25d3c74b949988c637571e696fc04b25
|b 9
|e Last author
|u dkfz
773 _ _ |a 10.1038/s41467-025-59813-z
|g Vol. 16, no. 1, p. 4581
|0 PERI:(DE-600)2553671-0
|n 1
|p 4581
|t Nature Communications
|v 16
|y 2025
|x 2041-1723
909 C O |o oai:inrepo02.dkfz.de:301495
|p VDB
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 0
|6 P:(DE-He78)3877ae274d0271d6bf311bb46539f013
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 1
|6 P:(DE-He78)0179ab69c93d0c5110458003dbc8af0c
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 3
|6 P:(DE-He78)704f69971aa28ce8ceb62c6118120ee2
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 4
|6 P:(DE-He78)07729a8a27f6637e3d284a1441a2cfb7
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 5
|6 P:(DE-He78)500ea2412dae05bdfe615df3d9bc2470
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 6
|6 P:(DE-He78)457c042884c901eb0a02c18bb1d30103
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 7
|6 P:(DE-He78)27152949302e3bd0d681a6f0548912b9
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 9
|6 P:(DE-He78)25d3c74b949988c637571e696fc04b25
913 1 _ |a DE-HGF
|b Gesundheit
|l Krebsforschung
|1 G:(DE-HGF)POF4-310
|0 G:(DE-HGF)POF4-314
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Immunologie und Krebs
|x 0
914 1 _ |y 2025
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b NAT COMMUN : 2022
|d 2025-01-02
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2025-01-02
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2025-01-02
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
|d 2024-01-30T07:48:07Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
|d 2024-01-30T07:48:07Z
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b DOAJ : Peer review
|d 2024-01-30T07:48:07Z
915 _ _ |a Creative Commons Attribution CC BY (No Version)
|0 LIC:(DE-HGF)CCBYNV
|2 V:(DE-HGF)
|b DOAJ
|d 2024-01-30T07:48:07Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2025-01-02
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1040
|2 StatID
|b Zoological Record
|d 2025-01-02
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1060
|2 StatID
|b Current Contents - Agriculture, Biology and Environmental Sciences
|d 2025-01-02
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1150
|2 StatID
|b Current Contents - Physical, Chemical and Earth Sciences
|d 2025-01-02
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2025-01-02
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2025-01-02
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2025-01-02
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2025-01-02
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2025-01-02
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2025-01-02
915 _ _ |a IF >= 15
|0 StatID:(DE-HGF)9915
|2 StatID
|b NAT COMMUN : 2022
|d 2025-01-02
915 _ _ |a Article Processing Charges
|0 StatID:(DE-HGF)0561
|2 StatID
|d 2025-01-02
915 _ _ |a Fees
|0 StatID:(DE-HGF)0700
|2 StatID
|d 2025-01-02
920 2 _ |0 I:(DE-He78)D400-20160331
|k D400
|l Pathologie infektionsbedingter Tumoren
|x 0
920 1 _ |0 I:(DE-He78)D400-20160331
|k D400
|l Pathologie infektionsbedingter Tumoren
|x 0
920 1 _ |0 I:(DE-He78)C060-20160331
|k C060
|l C060 Biostatistik
|x 1
920 0 _ |0 I:(DE-He78)D400-20160331
|k D400
|l Pathologie infektionsbedingter Tumoren
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-He78)D400-20160331
980 _ _ |a I:(DE-He78)C060-20160331
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21