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000301507 1001_ $$00000-0003-1049-6225$$aNaudin, Sabine$$b0
000301507 245__ $$aAlcohol intake and pancreatic cancer risk: An analysis from 30 prospective studies across Asia, Australia, Europe, and North America.
000301507 260__ $$aLawrence, Kan.$$bPLoS$$c2025
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000301507 520__ $$aAlcohol is a known carcinogen, yet the evidence for an association with pancreatic cancer risk is considered as limited or inconclusive by international expert panels. We examined the association between alcohol intake and pancreatic cancer risk in a large consortium of prospective studies.Population-based individual-level data was pooled from 30 cohorts across four continents, including Asia, Australia, Europe, and North America. A total of 2,494,432 participants without cancer at baseline (62% women, 84% European ancestries, 70% alcohol drinkers [alcohol intake ≥ 0.1 g/day], 47% never smokers) were recruited between 1980 and 2013 at the median age of 57 years and 10,067 incident pancreatic cancer cases were recorded. In age- and sex-stratified Cox proportional hazards models adjusted for smoking history, diabetes status, body mass index, height, education, race and ethnicity, and physical activity, pancreatic cancer hazard ratios (HR) and 95% confidence intervals (CI) were estimated for categories of alcohol intake and in continuous for a 10 g/day increase. Potential heterogeneity by sex, smoking status, geographic regions, and type of alcoholic beverage was investigated. Alcohol intake was positively associated with pancreatic cancer risk, with HR30-to-<60 g/day and HR≥60 g/day equal to 1.12 (95% CI [1.03,1.21]) and 1.32 (95% CI [1.18,1.47]), respectively, compared to intake of 0.1 to <5 g/day. A 10 g/day increment of alcohol intake was associated with a 3% increased pancreatic cancer risk overall (HR: 1.03; 95% CI [1.02,1.04]; pvalue < 0.001) and among never smokers (HR: 1.03; 95% CI [1.01,1.06]; pvalue = 0.006), with no evidence of heterogeneity by sex (pheterogeneity = 0.274) or smoking status (pheterogeneity = 0.624). Associations were consistent in Europe-Australia (HR10 g/day = 1.03, 95% CI [1.00,1.05]; pvalue = 0.042) and North America (HR10 g/day = 1.03, 95% CI [1.02,1.05]; pvalue < 0.001), while no association was observed in cohorts from Asia (HR10 g/day = 1.00, 95% CI [0.96,1.03]; pvalue = 0.800; pheterogeneity = 0.003). Positive associations with pancreatic cancer risk were found for alcohol intake from beer (HR10 g/day = 1.02, 95% CI [1.00,1.04]; pvalue = 0.015) and spirits/liquor (HR10 g/day = 1.04, 95% CI [1.03,1.06]; pvalue < 0.001), but not wine (HR10 g/day = 1.00, 95% CI [0.98,1.03]; pvalue = 0.827). The differential associations across geographic regions and types of alcoholic beverages might reflect differences in drinking habits and deserve more investigations.Findings from this large-scale pooled analysis support a modest positive association between alcohol intake and pancreatic cancer risk, irrespective of sex and smoking status. Associations were particularly evident for baseline alcohol intake of at least 15 g/day in women and 30 g/day in men.
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000301507 7001_ $$aWang, Molin$$b1
000301507 7001_ $$aDimou, Niki$$b2
000301507 7001_ $$aEbrahimi, Elmira$$b3
000301507 7001_ $$aGenkinger, Jeanine$$b4
000301507 7001_ $$00000-0001-9592-5791$$aAdami, Hans-Olov$$b5
000301507 7001_ $$aAlbanes, Demetrius$$b6
000301507 7001_ $$aBabic, Ana$$b7
000301507 7001_ $$aBarnett, Matt$$b8
000301507 7001_ $$00000-0002-5001-1088$$aBogumil, David$$b9
000301507 7001_ $$aCai, Hui$$b10
000301507 7001_ $$aChen, Chu$$b11
000301507 7001_ $$aEliassen, A Heather$$b12
000301507 7001_ $$aFreudenheim, Jo L$$b13
000301507 7001_ $$00000-0002-0165-5522$$aGierach, Gretchen$$b14
000301507 7001_ $$00000-0002-6123-0219$$aGiovannucci, Edward L$$b15
000301507 7001_ $$aGunter, Marc J$$b16
000301507 7001_ $$00000-0001-7673-5554$$aHåkansson, Niclas$$b17
000301507 7001_ $$aHirabayashi, Mayo$$b18
000301507 7001_ $$aHou, Tao$$b19
000301507 7001_ $$aHuang, Brian Z$$b20
000301507 7001_ $$aHuang, Wen-Yi$$b21
000301507 7001_ $$aJayasekara, Harindra$$b22
000301507 7001_ $$aJones, Michael E$$b23
000301507 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b24$$udkfz
000301507 7001_ $$00000-0002-5674-6341$$aKoh, Woon-Puay$$b25
000301507 7001_ $$aLacey, James V$$b26
000301507 7001_ $$00000-0001-6816-7577$$aLagerros, Ylva Trolle$$b27
000301507 7001_ $$aLarsson, Susanna C$$b28
000301507 7001_ $$aLiao, Linda M$$b29
000301507 7001_ $$00000-0003-4624-2737$$aLo, Kenneth$$b30
000301507 7001_ $$00000-0002-3573-8748$$aLoftfield, Erikka$$b31
000301507 7001_ $$aMacInnis, Robert J$$b32
000301507 7001_ $$aMännistö, Satu$$b33
000301507 7001_ $$aMcCullough, Marjorie L$$b34
000301507 7001_ $$aMiller, Anthony$$b35
000301507 7001_ $$00000-0001-5764-7268$$aMilne, Roger L$$b36
000301507 7001_ $$00000-0002-8169-1661$$aMoore, Steven C$$b37
000301507 7001_ $$aMucci, Lorelei A$$b38
000301507 7001_ $$aNeuhouser, Marian L$$b39
000301507 7001_ $$aPatel, Alpa V$$b40
000301507 7001_ $$00000-0003-3676-8954$$aPlatz, Elizabeth A$$b41
000301507 7001_ $$00000-0001-5924-6871$$aPrizment, Anna$$b42
000301507 7001_ $$00000-0002-2120-2280$$aRobien, Kim$$b43
000301507 7001_ $$aRohan, Thomas E$$b44
000301507 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b45
000301507 7001_ $$00000-0001-6994-4884$$aSandin, Sven$$b46
000301507 7001_ $$aSawada, Norie$$b47
000301507 7001_ $$aSchoemaker, Minouk$$b48
000301507 7001_ $$aShu, Xiao-Ou$$b49
000301507 7001_ $$aSinha, Rashmi$$b50
000301507 7001_ $$aSnetselaar, Linda$$b51
000301507 7001_ $$aStampfer, Meir J$$b52
000301507 7001_ $$aStolzenberg-Solomon, Rachael$$b53
000301507 7001_ $$aThomson, Cynthia A$$b54
000301507 7001_ $$00000-0003-4385-2097$$aTjønneland, Anne$$b55
000301507 7001_ $$00000-0001-5449-6230$$aUm, Caroline Y$$b56
000301507 7001_ $$00000-0001-8781-8099$$avan den Brandt, Piet A$$b57
000301507 7001_ $$aVisvanathan, Kala$$b58
000301507 7001_ $$aWang, Sophia S$$b59
000301507 7001_ $$aWang, Renwei$$b60
000301507 7001_ $$aWeiderpass, Elisabete$$b61
000301507 7001_ $$00000-0002-3834-1535$$aWeinstein, Stephanie J$$b62
000301507 7001_ $$aWhite, Emily$$b63
000301507 7001_ $$00000-0003-1458-7597$$aWillett, Walter$$b64
000301507 7001_ $$00000-0001-7387-6845$$aWoslk, Alicja$$b65
000301507 7001_ $$aWolpin, Brian M$$b66
000301507 7001_ $$aYaun, Shiaw-Shyuan S$$b67
000301507 7001_ $$aYuan, Chen$$b68
000301507 7001_ $$00000-0002-4620-3108$$aYuan, Jian-Min$$b69
000301507 7001_ $$00000-0003-1226-070X$$aZheng, Wei$$b70
000301507 7001_ $$aBrennan, Paul$$b71
000301507 7001_ $$00000-0003-3462-8608$$aSmith-Warner, Stephanie A$$b72
000301507 7001_ $$00000-0001-9358-7338$$aFerrari, Pietro$$b73
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