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@ARTICLE{Naudin:301507,
      author       = {S. Naudin and M. Wang and N. Dimou and E. Ebrahimi and J.
                      Genkinger and H.-O. Adami and D. Albanes and A. Babic and M.
                      Barnett and D. Bogumil and H. Cai and C. Chen and A. H.
                      Eliassen and J. L. Freudenheim and G. Gierach and E. L.
                      Giovannucci and M. J. Gunter and N. Håkansson and M.
                      Hirabayashi and T. Hou and B. Z. Huang and W.-Y. Huang and
                      H. Jayasekara and M. E. Jones and V. Katzke$^*$ and W.-P.
                      Koh and J. V. Lacey and Y. T. Lagerros and S. C. Larsson and
                      L. M. Liao and K. Lo and E. Loftfield and R. J. MacInnis and
                      S. Männistö and M. L. McCullough and A. Miller and R. L.
                      Milne and S. C. Moore and L. A. Mucci and M. L. Neuhouser
                      and A. V. Patel and E. A. Platz and A. Prizment and K.
                      Robien and T. E. Rohan and C. Sacerdote and S. Sandin and N.
                      Sawada and M. Schoemaker and X.-O. Shu and R. Sinha and L.
                      Snetselaar and M. J. Stampfer and R. Stolzenberg-Solomon and
                      C. A. Thomson and A. Tjønneland and C. Y. Um and P. A. van
                      den Brandt and K. Visvanathan and S. S. Wang and R. Wang and
                      E. Weiderpass and S. J. Weinstein and E. White and W.
                      Willett and A. Woslk and B. M. Wolpin and S. S. Yaun and C.
                      Yuan and J.-M. Yuan and W. Zheng and P. Brennan and S. A.
                      Smith-Warner and P. Ferrari},
      title        = {{A}lcohol intake and pancreatic cancer risk: {A}n analysis
                      from 30 prospective studies across {A}sia, {A}ustralia,
                      {E}urope, and {N}orth {A}merica.},
      journal      = {PLoS medicine},
      volume       = {22},
      number       = {5},
      issn         = {1549-1277},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {DKFZ-2025-01046},
      pages        = {e1004590 -},
      year         = {2025},
      abstract     = {Alcohol is a known carcinogen, yet the evidence for an
                      association with pancreatic cancer risk is considered as
                      limited or inconclusive by international expert panels. We
                      examined the association between alcohol intake and
                      pancreatic cancer risk in a large consortium of prospective
                      studies.Population-based individual-level data was pooled
                      from 30 cohorts across four continents, including Asia,
                      Australia, Europe, and North America. A total of 2,494,432
                      participants without cancer at baseline $(62\%$ women,
                      $84\%$ European ancestries, $70\%$ alcohol drinkers [alcohol
                      intake ≥ 0.1 g/day], $47\%$ never smokers) were recruited
                      between 1980 and 2013 at the median age of 57 years and
                      10,067 incident pancreatic cancer cases were recorded. In
                      age- and sex-stratified Cox proportional hazards models
                      adjusted for smoking history, diabetes status, body mass
                      index, height, education, race and ethnicity, and physical
                      activity, pancreatic cancer hazard ratios (HR) and $95\%$
                      confidence intervals (CI) were estimated for categories of
                      alcohol intake and in continuous for a 10 g/day increase.
                      Potential heterogeneity by sex, smoking status, geographic
                      regions, and type of alcoholic beverage was investigated.
                      Alcohol intake was positively associated with pancreatic
                      cancer risk, with HR30-to-<60 g/day and HR≥60 g/day equal
                      to 1.12 $(95\%$ CI [1.03,1.21]) and 1.32 $(95\%$ CI
                      [1.18,1.47]), respectively, compared to intake of 0.1 to <5
                      g/day. A 10 g/day increment of alcohol intake was associated
                      with a $3\%$ increased pancreatic cancer risk overall (HR:
                      1.03; $95\%$ CI [1.02,1.04]; pvalue < 0.001) and among never
                      smokers (HR: 1.03; $95\%$ CI [1.01,1.06]; pvalue = 0.006),
                      with no evidence of heterogeneity by sex (pheterogeneity =
                      0.274) or smoking status (pheterogeneity = 0.624).
                      Associations were consistent in Europe-Australia (HR10 g/day
                      = 1.03, $95\%$ CI [1.00,1.05]; pvalue = 0.042) and North
                      America (HR10 g/day = 1.03, $95\%$ CI [1.02,1.05]; pvalue <
                      0.001), while no association was observed in cohorts from
                      Asia (HR10 g/day = 1.00, $95\%$ CI [0.96,1.03]; pvalue =
                      0.800; pheterogeneity = 0.003). Positive associations with
                      pancreatic cancer risk were found for alcohol intake from
                      beer (HR10 g/day = 1.02, $95\%$ CI [1.00,1.04]; pvalue =
                      0.015) and spirits/liquor (HR10 g/day = 1.04, $95\%$ CI
                      [1.03,1.06]; pvalue < 0.001), but not wine (HR10 g/day =
                      1.00, $95\%$ CI [0.98,1.03]; pvalue = 0.827). The
                      differential associations across geographic regions and
                      types of alcoholic beverages might reflect differences in
                      drinking habits and deserve more investigations.Findings
                      from this large-scale pooled analysis support a modest
                      positive association between alcohol intake and pancreatic
                      cancer risk, irrespective of sex and smoking status.
                      Associations were particularly evident for baseline alcohol
                      intake of at least 15 g/day in women and 30 g/day in men.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40392909},
      doi          = {10.1371/journal.pmed.1004590},
      url          = {https://inrepo02.dkfz.de/record/301507},
}