%0 Journal Article
%A Schiele, Phillip
%A Japp, Alberto Sada
%A Stark, Regina
%A Sattelberg, Joanna J
%A Nikolaou, Christos
%A Kornhuber, Gereon
%A Abbasi, Parya
%A Ding, Nina
%A Rosnev, Stanislav
%A Meinke, Stefan
%A Mühle, Kerstin
%A Loyal, Lucie
%A Braun, Julian
%A Dingeldey, Manuela
%A Durlanik, Sibel
%A Matzmohr, Nadine
%A Ponikwicka-Tyszko, Donata
%A Wolczynski, Slawomir
%A Rahman, Nafis A
%A Taniuchi, Ichiro
%A Schlickeiser, Stephan
%A Giesecke-Thiel, Claudia
%A Blankenstein, Thomas
%A Na, Il-Kang
%A Thiel, Andreas
%A Frentsch, Marco
%T CD8+ T cell-derived CD40L mediates noncanonical cytotoxicity in CD40-expressing cancer cells.
%J Science advances
%V 11
%N 21
%@ 2375-2548
%C Washington, DC [u.a.]
%I Assoc.
%M DKFZ-2025-01050
%P eadr9331
%D 2025
%X T cells and their effector functions, in particular the canonical cytotoxicity of CD8+ T cells involving perforin, granzymes, Fas ligand (FasL), and tumor necrosis factor related apoptosis inducing ligand (TRAIL), are crucial for tumor immunity. Here, we reveal a previously unidentified mechanism by which CD40L-expressing CD8+ T cells induce cytotoxicity in cancer cells. In murine models, up to 50
%K CD8-Positive T-Lymphocytes: immunology
%K CD8-Positive T-Lymphocytes: metabolism
%K CD40 Ligand: metabolism
%K CD40 Ligand: genetics
%K CD40 Ligand: immunology
%K Animals
%K Humans
%K CD40 Antigens: metabolism
%K CD40 Antigens: genetics
%K Mice
%K Cell Line, Tumor
%K Neoplasms: immunology
%K Neoplasms: metabolism
%K Neoplasms: pathology
%K Neoplasms: genetics
%K Cytotoxicity, Immunologic
%K Signal Transduction
%K Caspase 8: metabolism
%K CD40 Ligand (NLM Chemicals)
%K CD40 Antigens (NLM Chemicals)
%K Caspase 8 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40397730
%R 10.1126/sciadv.adr9331
%U https://inrepo02.dkfz.de/record/301513