TY  - JOUR
AU  - Schiele, Phillip
AU  - Japp, Alberto Sada
AU  - Stark, Regina
AU  - Sattelberg, Joanna J
AU  - Nikolaou, Christos
AU  - Kornhuber, Gereon
AU  - Abbasi, Parya
AU  - Ding, Nina
AU  - Rosnev, Stanislav
AU  - Meinke, Stefan
AU  - Mühle, Kerstin
AU  - Loyal, Lucie
AU  - Braun, Julian
AU  - Dingeldey, Manuela
AU  - Durlanik, Sibel
AU  - Matzmohr, Nadine
AU  - Ponikwicka-Tyszko, Donata
AU  - Wolczynski, Slawomir
AU  - Rahman, Nafis A
AU  - Taniuchi, Ichiro
AU  - Schlickeiser, Stephan
AU  - Giesecke-Thiel, Claudia
AU  - Blankenstein, Thomas
AU  - Na, Il-Kang
AU  - Thiel, Andreas
AU  - Frentsch, Marco
TI  - CD8+ T cell-derived CD40L mediates noncanonical cytotoxicity in CD40-expressing cancer cells.
JO  - Science advances
VL  - 11
IS  - 21
SN  - 2375-2548
CY  - Washington, DC [u.a.]
PB  - Assoc.
M1  - DKFZ-2025-01050
SP  - eadr9331
PY  - 2025
AB  - T cells and their effector functions, in particular the canonical cytotoxicity of CD8+ T cells involving perforin, granzymes, Fas ligand (FasL), and tumor necrosis factor related apoptosis inducing ligand (TRAIL), are crucial for tumor immunity. Here, we reveal a previously unidentified mechanism by which CD40L-expressing CD8+ T cells induce cytotoxicity in cancer cells. In murine models, up to 50
KW  - CD8-Positive T-Lymphocytes: immunology
KW  - CD8-Positive T-Lymphocytes: metabolism
KW  - CD40 Ligand: metabolism
KW  - CD40 Ligand: genetics
KW  - CD40 Ligand: immunology
KW  - Animals
KW  - Humans
KW  - CD40 Antigens: metabolism
KW  - CD40 Antigens: genetics
KW  - Mice
KW  - Cell Line, Tumor
KW  - Neoplasms: immunology
KW  - Neoplasms: metabolism
KW  - Neoplasms: pathology
KW  - Neoplasms: genetics
KW  - Cytotoxicity, Immunologic
KW  - Signal Transduction
KW  - Caspase 8: metabolism
KW  - CD40 Ligand (NLM Chemicals)
KW  - CD40 Antigens (NLM Chemicals)
KW  - Caspase 8 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40397730
DO  - DOI:10.1126/sciadv.adr9331
UR  - https://inrepo02.dkfz.de/record/301513
ER  -