%0 Journal Article
%A Sprave, Tanja
%A Sahlmann, Jörg
%A Thomsen, Andreas R
%A Klein, Diana
%A Schäfer, Henning
%A Stoian, Raluca
%A Verma, Vivek
%A Grosu, Anca-Ligia
%A Ordonez, Elsa Beatriz Monroy
%T Does severe mucositis impair oncological outcome in head and neck cancer patients? A pooled analysis of two prospective studies with long-term follow-up.
%J BMC cancer
%V 25
%N 1
%@ 1471-2407
%C London
%I BioMed Central
%M DKFZ-2025-01055
%P 909
%D 2025
%X Oral mucositis (OM) is a frequently reported radiotherapy (RT)-induced acute toxicity in head and neck (H</td><td width="150">
%X N) cancer patients. Severe OM may be a dose-limiting condition, which can affect oncological outcomes. Therefore, we conducted a pooled analysis of two prospective studies with long-term follow-up to evaluate the impact of grade ≥3 OM on outcomes.This pooled analysis included 253 H</td><td width="150">
%X N cancer patients who received primary definitive or adjuvant chemoradiotherapy at the University of Freiburg Medical Center. Kaplan-Meier analyses with log-rank tests stratified for the presence of grade 3 OM were performed for overall survival (OS), local recurrence-free survival (LRFS), and distant-metastasis free survival (DMFS). Univariate Cox proportional hazards regression was performed to identify prognostic factors for OS, LRFS, and DMFS.The majority of participants had locally advanced disease: UICC stage IVA in 157 (62.1
%K Humans
%K Head and Neck Neoplasms: therapy
%K Head and Neck Neoplasms: mortality
%K Head and Neck Neoplasms: pathology
%K Head and Neck Neoplasms: complications
%K Male
%K Middle Aged
%K Female
%K Aged
%K Prospective Studies
%K Follow-Up Studies
%K Stomatitis: etiology
%K Stomatitis: pathology
%K Adult
%K Treatment Outcome
%K Prognosis
%K Aged, 80 and over
%K Chemoradiotherapy: adverse effects
%K Neoplasm Staging
%K Mucositis: etiology
%K Kaplan-Meier Estimate
%K Head and neck cancer (Other)
%K Mucositis (Other)
%K Radiation therapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40399815
%R 10.1186/s12885-025-14293-8
%U https://inrepo02.dkfz.de/record/301518