TY  - JOUR
AU  - Sprave, Tanja
AU  - Sahlmann, Jörg
AU  - Thomsen, Andreas R
AU  - Klein, Diana
AU  - Schäfer, Henning
AU  - Stoian, Raluca
AU  - Verma, Vivek
AU  - Grosu, Anca-Ligia
AU  - Ordonez, Elsa Beatriz Monroy
TI  - Does severe mucositis impair oncological outcome in head and neck cancer patients? A pooled analysis of two prospective studies with long-term follow-up.
JO  - BMC cancer
VL  - 25
IS  - 1
SN  - 1471-2407
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-01055
SP  - 909
PY  - 2025
AB  - Oral mucositis (OM) is a frequently reported radiotherapy (RT)-induced acute toxicity in head and neck (H</td><td width="150">
AB  - N) cancer patients. Severe OM may be a dose-limiting condition, which can affect oncological outcomes. Therefore, we conducted a pooled analysis of two prospective studies with long-term follow-up to evaluate the impact of grade ≥3 OM on outcomes.This pooled analysis included 253 H</td><td width="150">
AB  - N cancer patients who received primary definitive or adjuvant chemoradiotherapy at the University of Freiburg Medical Center. Kaplan-Meier analyses with log-rank tests stratified for the presence of grade 3 OM were performed for overall survival (OS), local recurrence-free survival (LRFS), and distant-metastasis free survival (DMFS). Univariate Cox proportional hazards regression was performed to identify prognostic factors for OS, LRFS, and DMFS.The majority of participants had locally advanced disease: UICC stage IVA in 157 (62.1
KW  - Humans
KW  - Head and Neck Neoplasms: therapy
KW  - Head and Neck Neoplasms: mortality
KW  - Head and Neck Neoplasms: pathology
KW  - Head and Neck Neoplasms: complications
KW  - Male
KW  - Middle Aged
KW  - Female
KW  - Aged
KW  - Prospective Studies
KW  - Follow-Up Studies
KW  - Stomatitis: etiology
KW  - Stomatitis: pathology
KW  - Adult
KW  - Treatment Outcome
KW  - Prognosis
KW  - Aged, 80 and over
KW  - Chemoradiotherapy: adverse effects
KW  - Neoplasm Staging
KW  - Mucositis: etiology
KW  - Kaplan-Meier Estimate
KW  - Head and neck cancer (Other)
KW  - Mucositis (Other)
KW  - Radiation therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40399815
DO  - DOI:10.1186/s12885-025-14293-8
UR  - https://inrepo02.dkfz.de/record/301518
ER  -