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@ARTICLE{Trautwein:301541,
      author       = {N. F. Trautwein and S. Mattern and M. Hinterleitner and G.
                      Reischl and R. Schirrmacher and V. Steger and S. Nadalin and
                      K. Nikolaou$^*$ and J. Schwenck and S. Singer and C. la
                      Fougère$^*$},
      title        = {{H}istologic {E}x {V}ivo {V}alidation of the
                      [18{F}]{SITATE} {S}omatostatin {R}eceptor {PET} {T}racer.},
      journal      = {Journal of nuclear medicine},
      volume       = {66},
      number       = {8},
      issn         = {0097-9058},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {DKFZ-2025-01062},
      pages        = {1204-1209},
      year         = {2025},
      note         = {2025 Aug 1;66(8):1204-1209},
      abstract     = {Radiolabeled somatostatin analogs (SSAs), such as
                      [68Ga]Ga-DOTA SSAs, have transformed imaging and therapeutic
                      strategies. However, their use is constrained by the high
                      cost of generators and their short half-life. In contrast,
                      [18F]SITATE presents a promising alternative, offering the
                      advantage of a longer half-life than 68Ga, along with the
                      cost-effectiveness of cyclotron-based production. This study
                      evaluated the first histologic ex vivo validation of
                      [18F]SITATE. Methods: This study retrospectively included 47
                      patients $(57\%$ male; mean age, 66.9 ± 14.9 y) with
                      histologically confirmed well-differentiated neuroendocrine
                      neoplasms who underwent [18F]SITATE PET followed by surgery
                      within 4 mo. Lesion uptake was quantified using SUVmean,
                      SUVpeak, SUVmax, and tumor-to-liver ratio (TLR). Histologic
                      somatostatin receptor (SSTR) type 2 expression was
                      determined using histological scores (H-scores), with
                      thresholds defining SSTR scores 1-3. The accuracy of PET
                      imaging for preoperative metastatic detection was evaluated
                      against surgical histology. Results: PET imaging
                      demonstrated a significant correlation between [18F]SITATE
                      uptake (SUVmean and TLR) and SSTR type 2 H-scores (r = 0.618
                      and 0.622, respectively; P < 0.0001). SSTR score 3
                      correlated with increased SUVmean and TLR (P < 0.0001).
                      Among 35 patients with primary resection and
                      lymphadenectomy, PET achieved a sensitivity of $73.9\%$ and
                      specificity of $100\%.$ Conclusion: [18F]SITATE PET imaging
                      strongly correlates with histologic SSTR expression,
                      demonstrating utility in staging and guiding therapeutic
                      decisions in neuroendocrine neoplasms. This 18F-labeled
                      tracer shows specificity comparable to historical
                      [68Ga]Ga-DOTA SSA data, whereas an increase in sensitivity
                      for the detection of locoregional metastases appears
                      possible. Further head-to-head comparisons of [18F]SITATE
                      with traditional [68Ga]Ga-DOTA SSA and histologic validation
                      are warranted to optimize its diagnostic accuracy and
                      clinical impact.},
      keywords     = {PET (Other) / SSTR PET (Other) / [18F]SITATE (Other) /
                      neuroendocrine neoplasms (Other) / oncology (Other) /
                      radiotracer tissue kinetics (Other)},
      cin          = {TU01},
      ddc          = {610},
      cid          = {I:(DE-He78)TU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40404394},
      doi          = {10.2967/jnumed.125.269619},
      url          = {https://inrepo02.dkfz.de/record/301541},
}