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@ARTICLE{Kumar:301543,
      author       = {R. Kumar and S. Das and W. Minka and C. Reiter and R.
                      Pereira and D. Fuhrmann and R. Schneider and A. Seshire and
                      C. Reusch and C. Conche and K. Imkeller and P. D. Pajevic
                      and D. S. Krause$^*$},
      title        = {{T}he role of the extracellular matrix protein {SPOCK}2 for
                      bone physiology and hematopoiesis.},
      journal      = {Bone},
      volume       = {198},
      issn         = {8756-3282},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2025-01064},
      pages        = {117539},
      year         = {2025},
      abstract     = {The bone marrow microenvironment (BMM) consists of
                      different cellular and acellular components. These
                      components synergize in regulating the process of
                      hematopoiesis. Various extracellular matrix proteins are
                      found amongst the acellular components. Secreted protein
                      acidic and rich in cysteine (SPARC) is amongst the most
                      abundant glycoproteins in bone. Sparc/osteonectin, cwcv, and
                      Kazal-like domains proteoglycan 2 (SPOCK2) is a member of
                      the SPARC family, and its role in bone metabolism and
                      hematopoiesis has not been investigated. Using female mice
                      deficient for SPOCK2, we assessed the role of SPOCK2 in
                      influencing bone formation, the BMM and hematopoiesis. Using
                      micro-computed tomography we found a significant decrease in
                      trabecular bone volume, bone mineral density and thickness,
                      but increased cortical mineral density in SPOCK2 knockout
                      (KO) versus wildtype (WT) bones. C-terminal telopeptide of
                      type I collagen, a measure of bone resorption, was
                      significantly increased in bone marrow supernatants of
                      SPOCK2 KO mice. In the hematopoietic compartment we found an
                      increase in hematopoietic stem cells, but a decrease of
                      mesenchymal stromal cells and adipocytes in the bone marrow
                      of SPOCK2 KO mice compared to control mice. Megakaryocytes
                      were increased in SPOCK2 KO mice. In summary, deficiency of
                      SPOCK2 leads to several alterations in the BMM. The
                      hematopoietic effects may be due to hematopoietic
                      cell-intrinsic effects in SPOCK2-deficient cells or due to a
                      SPOCK2-deficient niche or both.},
      keywords     = {Bone (Other) / Bone marrow microenvironment (Other) /
                      Extracellular matrix (Other) / Hematopoiesis (Other)},
      cin          = {FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40403823},
      doi          = {10.1016/j.bone.2025.117539},
      url          = {https://inrepo02.dkfz.de/record/301543},
}