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@ARTICLE{Chen:301544,
      author       = {X. Chen$^*$ and M. Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{D}eriving risk-adapted starting ages of breast cancer
                      screening according to polygenic risk score.},
      journal      = {JNCI cancer spectrum},
      volume       = {9},
      number       = {3},
      issn         = {2515-5091},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2025-01065},
      pages        = {pkaf056},
      year         = {2025},
      note         = {#EA:C070#LA:C070# / 2025 Apr 30;9(3):pkaf056},
      abstract     = {Breast cancer screening starting at age 50 has been
                      implemented in many countries. A recent recommendation of
                      the US Preventive Services Task Force recommends lowering
                      the starting age of breast cancer screening to 40. We aimed
                      to assess the potential use of a polygenic risk score (PRS)
                      for defining risk-adapted starting ages for women in the US
                      and various European countries as an alternative to
                      population-wide lowering of the starting age.We determined
                      5-year cumulative risks of breast cancer for women at
                      individual ages between 30 and 50 years in the US and four
                      large European countries (Germany, the UK, Italy, and
                      France) based on the Surveillance, Epidemiology, and End
                      Results program and GLOBOCAN 2022 database. Using relative
                      risks for women within certain percentile ranges of a
                      well-established PRS based on 313 risk variants (PRS313), we
                      determined at which ages women with higher PRS313 would
                      reach the breast cancer risk at age 50 of those at 'medium'
                      (40th to 60th percentile) risk.Non-Hispanic White women in
                      the US in PRS313 percentile categories 60-80, 80-90, 90-95,
                      95-99 and >99 would reach the medium 5-year cumulative risk
                      at age 50 already at ages 43, 41, 39, 37, 34, respectively.
                      Despite some variation in breast cancer incidence,
                      risk-adapted starting ages of screening were similar across
                      European countries.Consideration of a PRS would lead to
                      risk-adapted starting ages of screening for breast cancer
                      rather than a uniform advancement of starting age for White
                      women in the US and European countries.},
      keywords     = {breast cancer (Other) / polygenic risk score (Other) /
                      risk-adapted starting age (Other)},
      cin          = {C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40403333},
      doi          = {10.1093/jncics/pkaf056},
      url          = {https://inrepo02.dkfz.de/record/301544},
}