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000301545 1001_ $$00000-0002-8062-7246$$aBarilla, Rocky M$$b0
000301545 245__ $$aType 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense.
000301545 260__ $$aWashington, DC$$bAmerican Association for the Advancement of Science$$c2025
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000301545 520__ $$aEnteric nervous system (ENS)-derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is considerably lacking. Here, we characterized a primary enteric sensory neuron (PSN) subset producing the neuropeptides neuromedin U (NMU) and calcitonin gene-related peptide β (CGRPβ) and coexpressing receptors for the type 2 cytokines interleukin-4 (IL-4) and IL-13. Type 2 cytokines amplified NMU and CGRPβ expression in PSNs, in vitro and in vivo, which was abrogated by PSN-specific Il13ra1 deletion. Deletion of Il13ra1 in PSNs impaired host defense to the gastrointestinal helminth Heligmosomoides polygyrus and blunted muscularis immune responses. Co-administration of NMU23 and CGRPβ rescued helminth clearance deficits and restored anti-helminth immunity, highlighting the essential bi-directional neuro-immune crosstalk regulating intestinal type 2 inflammation.
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000301545 7001_ $$aBerard, Clara$$b1
000301545 7001_ $$aSun, Linyu$$b2
000301545 7001_ $$aSandhu, Sumiti$$b3
000301545 7001_ $$00000-0002-4467-6542$$aZaghouani, Sarah$$b4
000301545 7001_ $$00009-0004-0414-3540$$aIyer, Krishna S$$b5
000301545 7001_ $$0P:(DE-He78)ea8680ce6e1ca204110c90882c8b7b4b$$aAltun, Gizem$$b6$$udkfz
000301545 7001_ $$00000-0002-5457-9295$$aSu, Chien-Wen$$b7
000301545 7001_ $$00000-0001-9218-3040$$aDeguine, Jacques$$b8
000301545 7001_ $$aSingh, Vasundhara$$b9
000301545 7001_ $$00000-0001-7875-7087$$aHou, Yu$$b10
000301545 7001_ $$aKusumakar, Kanupriya$$b11
000301545 7001_ $$00009-0003-3657-1008$$aRutlin, Michael L$$b12
000301545 7001_ $$00000-0002-8194-9204$$aRao, Meenakshi$$b13
000301545 7001_ $$aZaghouani, Habib$$b14
000301545 7001_ $$aShi, Hai Ning$$b15
000301545 7001_ $$00000-0002-5630-5167$$aXavier, Ramnik J$$b16
000301545 7001_ $$00000-0001-7177-2110$$aKuchroo, Vijay K$$b17
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