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@ARTICLE{Diamond:301546,
      author       = {B. Diamond and D. Chahar and M. D. Jain and A. Poos$^*$ and
                      M. A. Durante and B. Ziccheddu and M. Kaddoura and M.
                      Papadimitriou and K. H. Maclachlan and T. Jelinek and F. E.
                      Davies and N. B. Figura and G. J. Morgan and E. K. Mai and
                      K. Weisel and R. Fenk and M.-S. Raab$^*$ and S. Usmani and
                      O. Landgren and F. L. Locke and H. Goldschmidt and J. H.
                      Schatz and N. Weinhold$^*$ and F. Maura},
      title        = {{M}utagenic impact and evolutionary influence of
                      chemo-radiotherapy in hematologic malignancies.},
      journal      = {Blood cancer discovery},
      volume       = {6},
      number       = {5},
      issn         = {2643-3230},
      address      = {Philadelphia, PA},
      publisher    = {American Association for Cancer Research},
      reportid     = {DKFZ-2025-01067},
      pages        = {450-463},
      year         = {2025},
      note         = {2025 Sep 3;6(5):450-463 / #EA:A360#LA:A360#},
      abstract     = {Ionizing radiotherapy (RT) is a widely used treatment
                      strategy for malignancies. In solid tumors, RT-induced
                      double-strand breaks lead to the accumulation of indels, and
                      their repair by non-homologous end-joining has been linked
                      to the ID8 mutational signature in surviving cells. However,
                      the extent of RT-induced mutagenesis in hematologic
                      malignancies and its impact on their mutational profiles and
                      interplay with commonly used chemotherapies has not yet been
                      explored. Here, we interrogated 580 whole-genome sequence
                      samples (WGS) from patients with large B-cell lymphoma,
                      multiple myeloma, and myeloid neoplasms and identified ID8
                      only in relapsed disease. Yet, ID8 was detected after
                      exposure to both RT and mutagenic chemotherapy (i.e.,
                      platinum and melphalan). Using WGS of single-cell colonies
                      derived from treated lymphoma cells, we revealed a
                      dose-response relationship between RT and platinum and ID8.
                      Finally, using ID8 as a genomic barcode we demonstrate that
                      a single RT-surviving cell may seed distant relapse.},
      cin          = {A360},
      ddc          = {610},
      cid          = {I:(DE-He78)A360-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40402512},
      doi          = {10.1158/2643-3230.BCD-24-0328},
      url          = {https://inrepo02.dkfz.de/record/301546},
}