%0 Journal Article
%A Kosmala, Rebekka
%A Hammann, Adriana Salazar
%A Paulus, Patrick
%A Zimmermann, Marcus
%A Wittig-Sauerwein, Andrea
%A Germer, Christoph-Thomas
%A Ghadimi, Michael
%A Hofheinz, Ralf-Dieter
%A Diefenhardt, Markus
%A Fokas, Emmanouil
%A Rödel, Claus
%A Polat, Bülent
%T Quality of life after two sequences of total neoadjuvant treatment in patients with locally advanced rectal cancer in the randomized CAO/ARO/AIO-12 phase 2 trial.
%J International journal of radiation oncology, biology, physics
%V nn
%@ 0360-3016
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2025-01090
%P nn
%D 2025
%Z epub
%X In a multicenter phase 2 trial the sequence of chemoradiotherapy (CRT) followed by consolidation chemotherapy (CT) prior to total mesorectal excision demonstrated higher pathological complete response rates than induction CT before CRT. Here, we present findings on quality of life (QoL).Patients with rectal carcinoma (cT3-4 cN0-2) were randomly assigned to group A (CT+CRT; N=156) or group B (CRT+CT; N=150). This is a secondary QoL analysis (EORTC QLQ-C30+CR29, Wexner) before and during treatment and of disease-free patients during follow-up.gov identifier: XXXX.At baseline, completed questionnaires were available for 86
%K Quality of life (Other)
%K chemoradiotherapy (Other)
%K clinical trial (Other)
%K radiotherapy (Other)
%K rectal neoplasms (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40409541
%R 10.1016/j.ijrobp.2025.05.018
%U https://inrepo02.dkfz.de/record/301582