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@ARTICLE{Beck:301587,
      author       = {A. Beck and L. Gabler-Pamer and G. Alencastro Veiga
                      Cruzeiro and S. Lambo$^*$ and B. Englinger and M. L. Shaw
                      and O. A. Hack and I. Liu and R. D. Haase and C. A. O. de
                      Biagi and A. Baumgartner and A. D. Nascimento Silva and M.
                      Klenner and P. S. Freidel and J. Herms and L. von
                      Baumgarten$^*$ and J. C. Tonn$^*$ and N. Thon$^*$ and K.
                      Bruckner and S. Madlener and L. Mayr and D. Senfter and A.
                      Peyrl and I. Slavc and D. Lötsch and C. Dorfer and R.
                      Geyregger and N. Amberg and C. Haberler and N. Mack$^*$ and
                      B. Schwalm$^*$ and S. Pfister$^*$ and A. Korshunov$^*$ and
                      L. C. Baird and E. Yang and S. N. Chi and S. Alexandrescu
                      and J. Gojo and M. Kool$^*$ and V. Hovestadt and M. G.
                      Filbin},
      title        = {{C}ellular hierarchies of embryonal tumors with
                      multilayered rosettes are shaped by oncogenic micro{RNA}s
                      and receptor-ligand interactions.},
      journal      = {Nature cancer},
      volume       = {6},
      number       = {6},
      issn         = {2662-1347},
      address      = {London},
      publisher    = {Nature Research},
      reportid     = {DKFZ-2025-01095},
      pages        = {1035-1055},
      year         = {2025},
      note         = {#LA:B062# / 2025 Jun;6(6):1035-1055},
      abstract     = {Embryonal tumor with multilayered rosettes (ETMR) is a
                      pediatric brain tumor with dismal prognosis. Characteristic
                      alterations of the chromosome 19 microRNA cluster (C19MC)
                      are observed in most ETMR; however, the ramifications of
                      C19MC activation and the complex cellular architecture of
                      ETMR remain understudied. Here we analyze 11 ETMR samples
                      from patients using single-cell transcriptomics and
                      multiplexed spatial imaging. We reveal a spatially distinct
                      cellular hierarchy that spans highly proliferative neural
                      stem-like cells and more differentiated neuron-like cells.
                      C19MC is predominantly expressed in stem-like cells and
                      controls a transcriptional network governing stemness and
                      lineage commitment, as resolved by genome-wide analysis of
                      microRNA-mRNA binding. Systematic analysis of
                      receptor-ligand interactions between malignant cell types
                      reveals fibroblast growth factor receptor and Notch
                      signaling as oncogenic pathways that can be successfully
                      targeted in preclinical models and in one patient with ETMR.
                      Our study provides fundamental insights into ETMR
                      pathobiology and a powerful rationale for more effective
                      targeted therapies.},
      cin          = {B062 / HD01 / B300 / MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B300-20160331 / I:(DE-He78)MU01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40419763},
      doi          = {10.1038/s43018-025-00964-9},
      url          = {https://inrepo02.dkfz.de/record/301587},
}