% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{SteinbergVorhoff:301713,
      author       = {H. L. Steinberg-Vorhoff and J. Haubold and S. Bauer and H.
                      Richly and J. T. Siveke$^*$ and J. Wimmer and L. Umutlu and
                      B. M. Schaarschmidt and J. M. Theysohn and J. M. Ludwig},
      title        = {{D}egradable {S}tarch {M}icrosphere {T}ransarterial
                      {C}hemoembolization as {S}alvage {T}herapy in {P}atients
                      with {U}veal {M}elanoma {L}iver {M}etastases.},
      journal      = {Journal of vascular and interventional radiology},
      volume       = {36},
      number       = {9},
      issn         = {1051-0443},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-01105},
      pages        = {1418-1426.e1},
      year         = {2025},
      note         = {2025 Sep;36(9):1418-1426.e1},
      abstract     = {To assess DSM-TACE retrospectively as salvage therapy in
                      patients with unresectable uveal melanoma (UM) liver
                      metastases and to identify prognostic factors for
                      survival.Fifty-five patients $(49.1\%$ male, median age 65
                      years) who underwent a median of two (range 1-12) DSM-TACE
                      treatments were included. Cox proportional hazard models for
                      uni- and multivariate analyses (hazard ratio, $95\%$
                      confidence interval [CI], p-value) and Kaplan-Meier analysis
                      were performed to determine the median overall survival and
                      time to progression (mOS/TTP; $95\%$ CI). Response
                      assessment was performed according to the RECIST 1.1
                      criteria.The median OS of the study cohort was 8.0 $(95\%$
                      CI: 6.7-9.3) months. Univariate analysis identified low
                      lactate dehydrogenase (LDH <2x the upper level of normal)
                      (0.26; 0.12-0.57, p<0.001), normal serum protein (0.32;
                      0.15-0.7, p=0.008), hepatic tumor burden $≤25\%$ (0.39;
                      0.19-0.78, p=0.007), and monthly tumor growth rate (TGR) ≤
                      $20\%$ before the first DSM-TACE (0.32; 0.14-0.7, p=0.005)
                      as predictors of prolonged mOS. Multivariate analysis
                      confirmed low LDH (mOS: 11.4 vs. 4.3 months, p=0.021) and
                      low TGR (mOS: 9.9 vs. 6.4 months, p=0.005) as independent
                      predictors. Median TTP was four months $(95\%CI:$ 3.1-5.7).
                      The best response observed was PR in $13.6\%,$ SD in
                      $65.9\%,$ and PD in $20.5\%,$ with mOS of 25 (13.5-31.6), 8
                      (7.1-9.8), and 4.4 (2.1-20.4) months, respectively.DSM-TACE
                      represents a salvage treatment option for UM patients with
                      liver metastases that can help control the tumor. Lower
                      pretreatment serum LDH levels and low TGR have been
                      associated with prolonged mOS. However, direct comparison
                      with alternative treatments is required.},
      keywords     = {Degradable starch microspheres (Other) / Liver metastases
                      (Other) / Transarterial chemoembolization (Other) / Tumor
                      growth rate (Other) / Uveal melanoma (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40436267},
      doi          = {10.1016/j.jvir.2025.05.020},
      url          = {https://inrepo02.dkfz.de/record/301713},
}