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@ARTICLE{TorresLaiton:301716,
      author       = {L. Torres-Laiton and L. Luján-Barroso and N.
                      Nadal-Zaragoza and C. Castro-Espin and P. Jakszyn and C.
                      Panico and C. Le Cornet$^*$ and C. C. Dahm and D. Petrova
                      and D. Á. Rodríguez-Palacios and F. Jannasch and G. Masala
                      and L. Dossus and L. Padroni and M. Guevara and M. B.
                      Schulze and R. T. Fortner and R. Tumino and M. Crous-Bou},
      title        = {{D}iabetes-{R}elated {D}ietary {P}atterns and {E}ndometrial
                      {C}ancer {R}isk and {S}urvival in the {E}uropean
                      {P}rospective {I}nvestigation into {C}ancer and {N}utrition
                      {S}tudy.},
      journal      = {Nutrients},
      volume       = {17},
      number       = {10},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2025-01108},
      pages        = {1645},
      year         = {2025},
      abstract     = {Endometrial cancer (EC)'s major risk factors include
                      obesity and diabetes, both strongly related with lifestyle
                      choices and dietary factors. Our study aimed to evaluate the
                      relationship between diabetes-related dietary patterns, EC
                      risk, and survival in a population of middle-aged European
                      women.A total of 285,418 female participants from the
                      European Prospective Investigation into Cancer and Nutrition
                      (EPIC) study were included in the analysis. After a mean
                      time of 10.6 years of follow-up, 1955 incident EC cases were
                      registered; of those, 133 women died from EC. The Empirical
                      Dietary Index for Insulin Resistance (EDIR), the Empirical
                      Dietary Index for Hyperinsulinemia (EDIH), and the Diabetes
                      Risk Reduction Diet (DRRD), were estimated from dietary
                      information collected at baseline from EPIC participants.
                      Cox proportional hazards regression models were used to
                      evaluate the association between the dietary patterns and EC
                      risk, using hazard ratios (HR), $95\%$ confidence intervals
                      (CI), and adjusting for relevant confounders. Cox and
                      Fine-Gray models were used to assess the association with
                      overall and EC-specific mortality, respectively.Higher
                      adherence to EDIR was associated with an increased risk of
                      EC, multivariable HR for T3vsT1 were 1.17 $(95\%$ CI = 1.04
                      to1.31). However, when BMI was included in the models, these
                      associations became weaker and no longer statistically
                      significant. No associations were observed in relation to
                      adherence to EDIH, DRRD, and EC risk. No associations were
                      found in relation to diabetes-related dietary patterns and
                      mortality.This study highlights the potential role of
                      diabetes related dietary patterns and EC etiology and
                      prevention. Further studies are warranted to better
                      understand the role of etiology-derived dietary patterns and
                      disease prevention and prognosis.},
      keywords     = {Humans / Female / Endometrial Neoplasms: mortality /
                      Endometrial Neoplasms: epidemiology / Endometrial Neoplasms:
                      etiology / Middle Aged / Prospective Studies / Europe:
                      epidemiology / Risk Factors / Diet: adverse effects /
                      Proportional Hazards Models / Feeding Behavior / Diabetes
                      Mellitus: epidemiology / Adult / Insulin Resistance /
                      Diabetes Mellitus, Type 2 / diabetes (Other) / dietary
                      patterns (Other) / endometrial cancer (Other) / etiology
                      (Other) / risk factors (Other) / survival (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40431387},
      pmc          = {pmc:PMC12114188},
      doi          = {10.3390/nu17101645},
      url          = {https://inrepo02.dkfz.de/record/301716},
}