TY  - JOUR
AU  - Teleanu, Maria-Veronica
AU  - Schneider, Annika
AU  - Ball, Claudia
AU  - Leber, Mathias Felix
AU  - Stange, Christoph
AU  - Krieghoff-Henning, Eva
AU  - Beck, Katja
AU  - Heilig, Christoph E
AU  - Kreutzfeldt, Simon
AU  - Kuster, Bernhard
AU  - Lipka, Daniel
AU  - Fröhling, Stefan
TI  - Celebrating Ulrik Ringborg: Multi-Omics-Based Patient Stratification for Precision Cancer Treatment.
JO  - Biomolecules
VL  - 15
IS  - 5
SN  - 2218-273X
CY  - Basel
PB  - MDPI
M1  - DKFZ-2025-01110
SP  - 693
PY  - 2025
N1  - #EA:B340#LA:B340# /  2025 May 10;15(5):693
AB  - Precision oncology is becoming a mainstay in the standard of care for cancer patients. Recent technological advancements have significantly lowered the cost of various tumor profiling approaches, broadening the reach of molecular diagnostics and improving patient access to precision oncology. In parallel, drug development and discovery pipelines continue to evolve, driving targeted therapeutic options forward. Yet, not all patients harboring actionable molecular alterations respond to these interventions, and existing therapies do not cover the entire spectrum of potential molecular targets. In this review, we examine the current suite of omics technologies employed in clinical settings and underscore their roles in deepening our understanding of tumor biology and optimizing patient stratification for targeted treatments. We also highlight relevant precision oncology trials and share our own experiences using multi-omics data within a molecular tumor board framework. Finally, we discuss areas for future exploration aimed at propelling precision oncology to new heights.
KW  - Humans
KW  - Precision Medicine: methods
KW  - Neoplasms: genetics
KW  - Neoplasms: metabolism
KW  - Neoplasms: drug therapy
KW  - Neoplasms: therapy
KW  - Genomics: methods
KW  - Proteomics: methods
KW  - Multiomics
KW  - molecular profiling (Other)
KW  - patient stratification (Other)
KW  - precision oncology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40427586
DO  - DOI:10.3390/biom15050693
UR  - https://inrepo02.dkfz.de/record/301718
ER  -