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@ARTICLE{Deng:301722,
      author       = {M. Y. Deng and S. L. N. Maas and G. Anil and P. Sievers$^*$
                      and J. Lischalk and E. Zhao and S. Rauh and I. Jessen and T.
                      Eichkorn and S. Regnery and L. Bauer and T. Held and P.
                      Hoegen-Sassmannshausen$^*$ and K. Seidensaal and J.
                      Hörner-Rieber$^*$ and S. M. Pfister$^*$ and A. Wick$^*$ and
                      W. Wick$^*$ and A. von Deimling$^*$ and K. Herfarth and C.
                      Jungk and S. M. Krieg and J. Debus$^*$ and F. Sahm$^*$ and
                      L. König},
      title        = {{P}ostoperative radiotherapy in subtotally-resected
                      recurrent {WHO} grade 1 meningiomas with
                      intermediate-/high-risk molecular profiles.},
      journal      = {Neuro-Oncology},
      volume       = {nn},
      issn         = {1522-8517},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2025-01114},
      pages        = {nn},
      year         = {2025},
      note         = {#LA:B300# / epub},
      abstract     = {Meningiomas represent the most common primary intracranial
                      tumors in adults, with WHO grade 1 typically associated with
                      favorable outcomes following gross total resection
                      (GTR).This retrospective study included patients with CNS
                      WHO grade 1 meningioma and available DNA methylation
                      profiles (n=210). Clinical tumor characteristics and
                      treatment course (e.g., surgical resection, extent of
                      resection, radiotherapy) were evaluated. Integrated Scores
                      (InS) were calculated based on methylation family using the
                      DKFZ brain tumor classifier, CNS WHO grading, and
                      chromosomal losses, categorized as low, intermediate, or
                      high. Survival analyses employed Kaplan-Meier and Cox
                      regression methods, with local progression-free survival
                      defined as primary endpoint.In newly diagnosed cases, GTR
                      was associated with a $93.0\%$ 3-year progression-free
                      survival (PFS), compared to $69.3\%$ following subtotal
                      resection (STR). Stratification by IntS showed that patients
                      in the IntS-low group had superior outcomes: 3-y PFS of 93.4
                      after GTR and $77.4\%$ after STR. In contrast, patients with
                      IntS-intermediate/high profiles showed significantly worse
                      outcomes, with PFS of $85.9\%$ after GTR and $40.0\%$ after
                      STR. Following tumor recurrence, particularly those with
                      IntS-intermediate/high, postoperative radiotherapy (RT)
                      after STR may improve 3-year PFS to $88.9\%,$ compared to
                      much lower PFS rates in newly diagnosed cases managed
                      without adjuvant RT after STR (3-year PFS: $40.0\%).Our$
                      findings highlight the combined impact of both the extent of
                      resection (EoR) and molecular risk profile on prognosis in
                      newly diagnosed cases. While conservative management is
                      feasible in lower-risk primary cases, recurrent or
                      higher-risk patients may benefit from early postoperative
                      RT.},
      keywords     = {WHO grade 1 meningioma (Other) / extent of resection
                      (Other) / integrated score (Other) / molecular diagnostics
                      (Other)},
      cin          = {B300 / HD01 / E050 / B062 / B320},
      ddc          = {610},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)E050-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)B320-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40424588},
      doi          = {10.1093/neuonc/noaf125},
      url          = {https://inrepo02.dkfz.de/record/301722},
}