%0 Journal Article
%A Mahmoud, Osama
%A Püllen, Lukas
%A Umutlu, Lale
%A Szarvas, Tibor
%A Fendler, Wolfgang P
%A Ting, Saskia
%A Reis, Henning
%A Bayer, Henning
%A Herrmann, Ken
%A Hadaschik, Boris A
%A Al-Nader, Mulham
%A Berliner, Christoph
%T Multitracer comparison of gold standard PSMA-PET/CT with 68Ga-FAPI and 18F-FDG in high-risk prostate cancer: a proof-of-concept study.
%J European journal of nuclear medicine and molecular imaging
%V nn
%@ 1619-7070
%C Heidelberg [u.a.]
%I Springer-Verl.
%M DKFZ-2025-01116
%P nn
%D 2025
%Z epub
%X The aim of this study was to, evaluate the diagnostic accuracy of [⁶⁸Ga]Ga-FAPI-46 positron emission tomography (PET)/computed tomography (CT) in high-risk prostate cancer (PC) compared to [¹⁸F]PSMA / [⁶⁸Ga]Ga- PSMA- and [¹⁸F]FDG- PET/CT as well as multiparametric magnetic resonance imaging (MRI).Ten patients with high-risk PC (PSA > 20 ng/mL, Gleason score > 7, or > T2c) underwent PET/CT imaging using [⁶⁸Ga]Ga-FAPI-46, [¹⁸F]F-/[⁶⁸Ga]Ga-PSMA and [¹⁸F]FDG before radical prostatectomy (RP). The maximum standardized uptake values (SUVmax) were measured for the entire prostate and individual prostate sextants. Diagnostic accuracy was assessed per patient and per segment by correlating imaging findings with final histopathologic results. Immunohistochemical analysis of PSMA and FAP expression was performed on the index tumor lesion.Histopathologic analysis confirmed pT2c and pT3 prostate adenocarcinoma in 4 (40
%K Fibroblast activation protein (Other)
%K Fluorodeoxyglucose F18 (Other)
%K Positron emission tomography (Other)
%K Prostate neoplasms (Other)
%K Prostate-specific membrane antigen (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40423777
%R 10.1007/s00259-025-07352-6
%U https://inrepo02.dkfz.de/record/301724