%0 Journal Article
%A Bull, Emma C
%A Singh, Archana
%A Harden, Amy M
%A Soanes, Kirsty
%A Habash, Hala
%A Toracchio, Lisa
%A Carrabotta, Marianna
%A Schreck, Christina
%A Shah, Karan M
%A Riestra, Paulina Velasco
%A Chantoiseau, Margaux
%A Da Costa, Maria Eugénia Marques
%A Moquin-Beaudry, Gaël
%A Pantziarka, Pan
%A Essiet, Edidiong Akanimo
%A Gerrand, Craig
%A Gartland, Alison
%A Bojmar, Linda
%A Fahlgren, Anna
%A Marchais, Antonin
%A Papakonstantinou, Evgenia
%A Tomazou, Eleni M
%A Surdez, Didier
%A Heymann, Dominique
%A Cidre-Aranaz, Florencia
%A Fromigue, Olivia
%A Sexton, Darren W
%A Herold, Nikolas
%A Grünewald, Thomas G P
%A Scotlandi, Katia
%A Nathrath, Michaela
%A Green, Darrell
%T Targeting metastasis in paediatric bone sarcomas.
%J Molecular cancer
%V 24
%N 1
%@ 1476-4598
%C London
%I Biomed Central
%M DKFZ-2025-01120
%P 153
%D 2025
%X Paediatric bone sarcomas (e.g. Ewing sarcoma, osteosarcoma) comprise significant biological and clinical heterogeneity. This extreme heterogeneity affects response to systemic therapy, facilitates inherent and acquired drug resistance and possibly underpins the origins of metastatic disease, a key component implicit in cancer related death. Across all cancers, metastatic models have offered competing accounts on when dissemination occurs, either early or late during tumorigenesis, whether metastases at different foci arise independently and directly from the primary tumour or give rise to each other, i.e. metastases-to-metastases dissemination, and whether cell exchange occurs between synchronously growing lesions. Although it is probable that all the above mechanisms can lead to metastatic disease, clinical observations indicate that distinct modes of metastasis might predominate in different cancers. Around 70
%K Humans
%K Bone Neoplasms: pathology
%K Bone Neoplasms: drug therapy
%K Child
%K Osteosarcoma: pathology
%K Osteosarcoma: drug therapy
%K Neoplasm Metastasis
%K Tumor Microenvironment: drug effects
%K Sarcoma, Ewing: pathology
%K Sarcoma, Ewing: drug therapy
%K Molecular Targeted Therapy
%K Biomarkers, Tumor
%K Prognosis
%K Bone (Other)
%K Ewing sarcoma (Other)
%K Metastasis (Other)
%K Osteosarcoma (Other)
%K Sarcoma (Other)
%K Biomarkers, Tumor (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40442778
%R 10.1186/s12943-025-02365-z
%U https://inrepo02.dkfz.de/record/301728