TY  - JOUR
AU  - Bull, Emma C
AU  - Singh, Archana
AU  - Harden, Amy M
AU  - Soanes, Kirsty
AU  - Habash, Hala
AU  - Toracchio, Lisa
AU  - Carrabotta, Marianna
AU  - Schreck, Christina
AU  - Shah, Karan M
AU  - Riestra, Paulina Velasco
AU  - Chantoiseau, Margaux
AU  - Da Costa, Maria Eugénia Marques
AU  - Moquin-Beaudry, Gaël
AU  - Pantziarka, Pan
AU  - Essiet, Edidiong Akanimo
AU  - Gerrand, Craig
AU  - Gartland, Alison
AU  - Bojmar, Linda
AU  - Fahlgren, Anna
AU  - Marchais, Antonin
AU  - Papakonstantinou, Evgenia
AU  - Tomazou, Eleni M
AU  - Surdez, Didier
AU  - Heymann, Dominique
AU  - Cidre-Aranaz, Florencia
AU  - Fromigue, Olivia
AU  - Sexton, Darren W
AU  - Herold, Nikolas
AU  - Grünewald, Thomas G P
AU  - Scotlandi, Katia
AU  - Nathrath, Michaela
AU  - Green, Darrell
TI  - Targeting metastasis in paediatric bone sarcomas.
JO  - Molecular cancer
VL  - 24
IS  - 1
SN  - 1476-4598
CY  - London
PB  - Biomed Central
M1  - DKFZ-2025-01120
SP  - 153
PY  - 2025
AB  - Paediatric bone sarcomas (e.g. Ewing sarcoma, osteosarcoma) comprise significant biological and clinical heterogeneity. This extreme heterogeneity affects response to systemic therapy, facilitates inherent and acquired drug resistance and possibly underpins the origins of metastatic disease, a key component implicit in cancer related death. Across all cancers, metastatic models have offered competing accounts on when dissemination occurs, either early or late during tumorigenesis, whether metastases at different foci arise independently and directly from the primary tumour or give rise to each other, i.e. metastases-to-metastases dissemination, and whether cell exchange occurs between synchronously growing lesions. Although it is probable that all the above mechanisms can lead to metastatic disease, clinical observations indicate that distinct modes of metastasis might predominate in different cancers. Around 70
KW  - Humans
KW  - Bone Neoplasms: pathology
KW  - Bone Neoplasms: drug therapy
KW  - Child
KW  - Osteosarcoma: pathology
KW  - Osteosarcoma: drug therapy
KW  - Neoplasm Metastasis
KW  - Tumor Microenvironment: drug effects
KW  - Sarcoma, Ewing: pathology
KW  - Sarcoma, Ewing: drug therapy
KW  - Molecular Targeted Therapy
KW  - Biomarkers, Tumor
KW  - Prognosis
KW  - Bone (Other)
KW  - Ewing sarcoma (Other)
KW  - Metastasis (Other)
KW  - Osteosarcoma (Other)
KW  - Sarcoma (Other)
KW  - Biomarkers, Tumor (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40442778
DO  - DOI:10.1186/s12943-025-02365-z
UR  - https://inrepo02.dkfz.de/record/301728
ER  -