%0 Journal Article
%A Wasilewski, David
%A Shaked, Zoe
%A Fuchs, Annalena
%A Roohani, Siyer
%A Xu, Ran
%A Schlaak, Max
%A Frost, Nikolaj
%A Misch, Martin
%A Capper, David
%A Kaul, David
%A Onken, Julia
%A Vajkoczy, Peter
%A Ehret, Felix
%T Re-resection of brain metastases - outcomes of an institutional cohort study and literature review.
%J BMC cancer
%V 25
%N 1
%@ 1471-2407
%C London
%I BioMed Central
%M DKFZ-2025-01132
%P 973
%D 2025
%X Surgically accessible brain metastases are treated through microsurgical removal followed by radiation therapy, resulting in improved progression-free and overall survival. Some patients experience recurrence, prompting the need for effective management strategies. Despite the prevalence of recurrence, there remains a gap in the literature regarding the outcomes of patients undergoing re-resection of brain metastases.This study aims to comprehensively characterize clinical, radiological, histopathological, and treatment-related aspects, along with outcomes, for patients undergoing re-resection of locally and distantly recurrent brain metastases.We conducted a single-center retrospective cohort study, including patients who underwent secondary brain metastasis resection following prior primary brain metastasis resection and irradiation.Among 60 patients, 41 (68.3
%K Humans
%K Brain Neoplasms: secondary
%K Brain Neoplasms: surgery
%K Brain Neoplasms: mortality
%K Female
%K Male
%K Middle Aged
%K Aged
%K Retrospective Studies
%K Neoplasm Recurrence, Local: surgery
%K Neoplasm Recurrence, Local: pathology
%K Adult
%K Reoperation
%K Treatment Outcome
%K Lung Neoplasms: pathology
%K Aged, 80 and over
%K Carcinoma, Non-Small-Cell Lung: pathology
%K Brain metastasis (Other)
%K Breast cancer (Other)
%K Lung cancer (Other)
%K Melanoma (Other)
%K Radiotherapy (Other)
%K Re-resection (Other)
%K Resection (Other)
%K Survival (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40452031
%R 10.1186/s12885-025-13677-0
%U https://inrepo02.dkfz.de/record/301748