%0 Journal Article
%A Al-Monajjed, Rouvier
%A Boschheidgen, Matthias
%A Lakes, Jale
%A Krilaviciute, Agne
%A Radtke, Jan-Philipp
%A Schlemmer, Heinz-Peter
%A Bonekamp, David
%A Herkommer, Kathleen
%A Jahnen, Matthias
%A Gschwend, Jürgen E
%A Düx, Daniel
%A Wacker, Frank
%A Makowski, Marcus R
%A Sauter, Andreas
%A Kuczyk, Markus A
%A Harke, Nina
%A Debus, Jürgen
%A Grott, Christoph
%A Arsov, Christian
%A Seibold, Petra
%A Hadaschik, Boris
%A Giesel, Frederik
%A Kristiansen, Glenn
%A Antoch, Gerald
%A Becker, Nikolaus
%A Kaaks, Rudolf
%A Schimmöller, Lars
%A Albers, Peter
%T Prostate Cancer Detection in Younger Men: A Comparative Analysis of Systematic and Magnetic Resonance Imaging-targeted Biopsy in the PROBASE Trial.
%J European urology
%V 88
%N 3
%@ 0302-2838
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2025-01143
%P 240-244
%D 2025
%Z #EA:C130#LA:C130# / 2025 Sep;88(3):240-244
%X The optimal approach for prostate cancer (PC) screening, including the ideal starting age and most effective diagnostic method, remains under investigation. We evaluated the diagnostic performance of magnetic resonance imaging (MRI)-targeted biopsy (TBx) and systematic biopsy (SBx) in detecting clinically significant PC (csPC) in men aged 45-50 yr in PROBASE, a prospective, randomized trial of a risk-adapted screening strategy. A total of 525 participants with elevated prostate-specific antigen (≥3 ng/ml) underwent MRI followed by biopsy. Of the 209 PC cases detected, 148 (71
%K Fusion biopsy (Other)
%K Magnetic resonance imaging (Other)
%K Prostate cancer (Other)
%K Prostate-specific antigen (Other)
%K Risk-adapted screening (Other)
%K Ultrasound (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40461322
%R 10.1016/j.eururo.2025.05.020
%U https://inrepo02.dkfz.de/record/301763