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@ARTICLE{AlMonajjed:301763,
      author       = {R. Al-Monajjed$^*$ and M. Boschheidgen and J. Lakes and A.
                      Krilaviciute$^*$ and J.-P. Radtke and H.-P. Schlemmer$^*$
                      and D. Bonekamp$^*$ and K. Herkommer and M. Jahnen and J. E.
                      Gschwend and D. Düx and F. Wacker and M. R. Makowski and A.
                      Sauter and M. A. Kuczyk and N. Harke and J. Debus and C.
                      Grott and C. Arsov and P. Seibold$^*$ and B. Hadaschik$^*$
                      and F. Giesel and G. Kristiansen and G. Antoch and N.
                      Becker$^*$ and R. Kaaks$^*$ and L. Schimmöller and P.
                      Albers$^*$},
      title        = {{P}rostate {C}ancer {D}etection in {Y}ounger {M}en: {A}
                      {C}omparative {A}nalysis of {S}ystematic and {M}agnetic
                      {R}esonance {I}maging-targeted {B}iopsy in the {PROBASE}
                      {T}rial.},
      journal      = {European urology},
      volume       = {88},
      number       = {3},
      issn         = {0302-2838},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2025-01143},
      pages        = {240-244},
      year         = {2025},
      note         = {#EA:C130#LA:C130# / 2025 Sep;88(3):240-244},
      abstract     = {The optimal approach for prostate cancer (PC) screening,
                      including the ideal starting age and most effective
                      diagnostic method, remains under investigation. We evaluated
                      the diagnostic performance of magnetic resonance imaging
                      (MRI)-targeted biopsy (TBx) and systematic biopsy (SBx) in
                      detecting clinically significant PC (csPC) in men aged 45-50
                      yr in PROBASE, a prospective, randomized trial of a
                      risk-adapted screening strategy. A total of 525 participants
                      with elevated prostate-specific antigen (≥3 ng/ml)
                      underwent MRI followed by biopsy. Of the 209 PC cases
                      detected, 148 $(71\%)$ were csPC. SBx identified $94\%$ of
                      csPC cases, while TBx detected $74\%$ (p ≤ 0.05). SBx also
                      diagnosed significantly more low-grade PCs than TBx (p <
                      0.001). These findings suggest that relying solely on
                      MRI-TBx may lead to underdiagnosis of csPC. Combining SBx
                      with TBx remains the most effective strategy for early
                      detection of PC in young men undergoing screening. Future
                      research should explore optimization strategies to reduce
                      unnecessary biopsies while maintaining high detection rates
                      for csPC. This trial is registered on the ISRCTN registry as
                      ISRCTN37591328 (https://www.isrctn.com/ISRCTN37591328). The
                      study protocol can be accessed at
                      https://doi.org/10.1016/j.eururo.2013.05.022.},
      keywords     = {Fusion biopsy (Other) / Magnetic resonance imaging (Other)
                      / Prostate cancer (Other) / Prostate-specific antigen
                      (Other) / Risk-adapted screening (Other) / Ultrasound
                      (Other)},
      cin          = {C130 / E010 / ED01 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C130-20160331 / I:(DE-He78)E010-20160331 /
                      I:(DE-He78)ED01-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40461322},
      doi          = {10.1016/j.eururo.2025.05.020},
      url          = {https://inrepo02.dkfz.de/record/301763},
}