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000301765 1001_ $$aNiedermayer, Fiona$$b0
000301765 245__ $$aAssociations of road traffic noise with adipose tissue depots and hepatic fat content - Results from the German National Cohort (NAKO).
000301765 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2025
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000301765 520__ $$aLittle is known about the relation between traffic noise exposure, an established environmental risk factor for cardiovascular disease, and early obesity-related risk markers such as adipose tissue (AT) and hepatic fat. Therefore, we aimed to assess associations of long-term road traffic noise exposure with AT depots measures from whole-body magnetic resonance imaging (MRI). We analyzed cross-sectional data from 11,343 participants from the population-based German National Cohort (NAKO) who underwent MRI examination between 2014 and 2016, considering visceral (VAT), subcutaneous abdominal (SCAAT), subcutaneous thoracic AT (SCTAT) and hepatic fat content as outcomes. Annual road traffic noise (Lden) data from the year 2017 (source: central EIONET data repository) was used to calculate weighted mean noise levels on a continuous scale within 10 and 100-meter buffers of participants' residencies. Among 11,101 participants with complete outcome data, 48.7 % were women, and the mean age was 51.9 years. Higher annual Lden was associated with increased AT depots and hepatic fat content in men (e.g., VAT: 1.72 %-change [95 % confidence interval: [0.14 %; 3.30 %]; SCAAT: 2.18 %-change [0.43 %; 3.93 %], hepatic fat content: 3.57 %-change [1.41 %; 5.78 %] per 10 dB(A) increase in Lden (10 m)) and women (e.g., VAT: 3.13 %-change [1.09 %; 5.18 %]; SCAAT: 2.38 %-change [0.55 %; 4.20 %], hepatic fat content: 3.08 %-change [1.00 %; 5.21 %] per 10 dB(A) increase in Lden (10 m)). Associations were robust with all outcomes after adjusting for air pollutants and surrounding greenness, and effect modification by obesity and hypertension was observed for SCAAT, SCTAT and hepatic fat content. Our findings indicate that annual exposure to road traffic noise is associated with increased adipose tissue depots and hepatic fat content, and thus present novel evidence for the cross-sectional association between noise and early MRI-derived metabolic health markers.
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000301765 650_7 $$2Other$$aEnvironment
000301765 650_7 $$2Other$$aHepatic steatosis
000301765 650_7 $$2Other$$aMetabolic disease
000301765 650_7 $$2Other$$aObesity
000301765 7001_ $$aRospleszcz, Susanne$$b1
000301765 7001_ $$aMatthiessen, Clara$$b2
000301765 7001_ $$aHoffmann, Barbara$$b3
000301765 7001_ $$aStoecklein, Sophia$$b4
000301765 7001_ $$aHaueise, Tobias$$b5
000301765 7001_ $$0P:(DE-He78)a70f21a2bf78bbc1306c3d432ae08dc7$$aNorajitra, Tobias$$b6$$udkfz
000301765 7001_ $$aSchlett, Christopher L$$b7
000301765 7001_ $$aNattenmüller, Johanna$$b8
000301765 7001_ $$aBamberg, Fabian$$b9
000301765 7001_ $$aMachann, Jürgen$$b10
000301765 7001_ $$aGünther, Matthias$$b11
000301765 7001_ $$aHirsch, Jochen$$b12
000301765 7001_ $$aNagrani, Rajini$$b13
000301765 7001_ $$aVölzke, Henry$$b14
000301765 7001_ $$aMeinke-Franze, Claudia$$b15
000301765 7001_ $$aHosten, Norbert$$b16
000301765 7001_ $$aNonnenmacher, Tobias$$b17
000301765 7001_ $$aBudai, Bettina Katalin$$b18
000301765 7001_ $$aPalm, Viktoria$$b19
000301765 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b20$$udkfz
000301765 7001_ $$0P:(DE-He78)e0ac0d57cdb66d87f2d95ae5f6178c1b$$aGreiser, Karin Halina$$b21$$udkfz
000301765 7001_ $$aSchulz-Menger, Jeanette$$b22
000301765 7001_ $$aNiendorf, Thoralf$$b23
000301765 7001_ $$aEndemann, Beate$$b24
000301765 7001_ $$aPischon, Tobias$$b25
000301765 7001_ $$aStaab, Jeroen$$b26
000301765 7001_ $$aDallavalle, Marco$$b27
000301765 7001_ $$aSchneider, Alexandra$$b28
000301765 7001_ $$aWolf, Kathrin$$b29
000301765 7001_ $$aPeters, Annette$$b30
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