%0 Journal Article
%A Alhalabi, Obada T
%A Klein, Lukas
%A Wasilewski, David
%A Mellal, Amine
%A Büsken, Carmen
%A Buszello, Clara
%A Cossu, Giulia
%A Eyüpoglu, Ilker Y
%A Unterberg, Andreas W
%A Vajkoczy, Peter
%A Schackert, Gabriele
%A Messerer, Mahmoud
%A Misch, Martin
%A Kessler, Tobias
%A Wick, Wolfgang
%A Jungk, Christine
%A El Damaty, Ahmed
%A Krieg, Sandro M
%A Juratli, Tareq A
%A Younsi, Alexander
%T Managing hydrocephalus in patients with leptomeningeal disease: A multicenter retrospective analysis.
%J International journal of cancer
%V 157
%N 8
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2025-01151
%P 1613-1624
%D 2025
%Z 2025 Oct 15;157(8):1613-1624
%X Leptomeningeal disease (LMD) represents a terminal condition of tumor cell seeding that can cause symptomatic hydrocephalus. With improved survival rates under systemic therapy, the role of cerebrospinal fluid (CSF) drainage through ventriculo-peritoneal shunt (VPS) or Rickham reservoir (RR) placement in LMD patients is gaining more relevance. This study aimed to compare outcomes of both modalities in a multicentric contemporary cohort. A retrospective analysis of medical charts in patients receiving VPS for LMD and malresorptive hydrocephalus in two neurosurgical centers between 2006 and 2021 yielded 64 patients. The most common underlying oncological conditions were breast (n = 32, 49
%K CSF diversion (Other)
%K Rickham reservoir (Other)
%K intrathecal therapy (Other)
%K leptomeningeal disease (Other)
%K ventriculoperitoneal shunt (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40464488
%R 10.1002/ijc.35505
%U https://inrepo02.dkfz.de/record/301771