TY  - JOUR
AU  - Alhalabi, Obada T
AU  - Klein, Lukas
AU  - Wasilewski, David
AU  - Mellal, Amine
AU  - Büsken, Carmen
AU  - Buszello, Clara
AU  - Cossu, Giulia
AU  - Eyüpoglu, Ilker Y
AU  - Unterberg, Andreas W
AU  - Vajkoczy, Peter
AU  - Schackert, Gabriele
AU  - Messerer, Mahmoud
AU  - Misch, Martin
AU  - Kessler, Tobias
AU  - Wick, Wolfgang
AU  - Jungk, Christine
AU  - El Damaty, Ahmed
AU  - Krieg, Sandro M
AU  - Juratli, Tareq A
AU  - Younsi, Alexander
TI  - Managing hydrocephalus in patients with leptomeningeal disease: A multicenter retrospective analysis.
JO  - International journal of cancer
VL  - 157
IS  - 8
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2025-01151
SP  - 1613-1624
PY  - 2025
N1  - 2025 Oct 15;157(8):1613-1624
AB  - Leptomeningeal disease (LMD) represents a terminal condition of tumor cell seeding that can cause symptomatic hydrocephalus. With improved survival rates under systemic therapy, the role of cerebrospinal fluid (CSF) drainage through ventriculo-peritoneal shunt (VPS) or Rickham reservoir (RR) placement in LMD patients is gaining more relevance. This study aimed to compare outcomes of both modalities in a multicentric contemporary cohort. A retrospective analysis of medical charts in patients receiving VPS for LMD and malresorptive hydrocephalus in two neurosurgical centers between 2006 and 2021 yielded 64 patients. The most common underlying oncological conditions were breast (n = 32, 49
KW  - CSF diversion (Other)
KW  - Rickham reservoir (Other)
KW  - intrathecal therapy (Other)
KW  - leptomeningeal disease (Other)
KW  - ventriculoperitoneal shunt (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40464488
DO  - DOI:10.1002/ijc.35505
UR  - https://inrepo02.dkfz.de/record/301771
ER  -