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@ARTICLE{Novruzov:301886,
      author       = {E. Novruzov and G. T. Sheikh and E. Mamlins and A.
                      Holzgreve and Y. Mori and S. Ledderose and F. Klauschen and
                      T. Watabe and M. A. Gorin and M. G. Pomper and K.
                      Herrmann$^*$ and S. P. Rowe and R. A. Werner and F. L.
                      Giesel},
      title        = {{M}eeting {U}pcoming {C}linical and {D}iagnostic {N}eeds in
                      {O}ncologic {I}maging: {A} {S}tructured {R}eporting {S}ystem
                      for {F}ibroblast-{A}ctivation-{P}rotein-{T}argeted
                      {I}maging-{FAP}-{RADS} {V}ersion 1.0.},
      journal      = {Journal of nuclear medicine},
      volume       = {66},
      number       = {8},
      issn         = {0097-9058},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {DKFZ-2025-01165},
      pages        = {1245-1251},
      year         = {2025},
      note         = {2025 Aug 1;66(8):1245-1251},
      abstract     = {Fibroblast activation protein (FAP)-targeted imaging has
                      emerged as a promising diagnostic tool for various oncologic
                      and nononcologic conditions. However, the increasing
                      employment of FAP-targeted imaging with small-molecule
                      radiotracers mandates a standardized reporting system to
                      ensure consistent interpretation across various clinical
                      scenarios, especially in oncologic imaging. This study
                      proposes an FAP reporting and data system (RADS) framework
                      (FAP-RADS version 1.0) to address those needs, aiming to
                      standardize FAP-targeted imaging reports, improve clinical
                      communication, and support multicenter research. Methods: We
                      conducted a comprehensive literature review and combined the
                      findings with expert consensus in nuclear medicine to design
                      a new scoring system based on the principles of the
                      molecular imaging RADS framework. FAP-RADS version 1.0 is
                      intended for use across multiple tumor types with variable
                      radiotracer uptake patterns and is nonspecific to imaging
                      modality (FAP PET and FAP SPECT) and radiotracer compound
                      structure. We aimed to ensure that the system would be
                      user-friendly and applicable to routine clinical practice.
                      Results: FAP-RADS version 1.0 introduces a 5-point scale to
                      assess the likelihood of malignancy in lesions based on the
                      imaging characteristics of the lesions. The scoring system
                      can be applied to different FAP ligands with varying
                      pharmacokinetics. The framework does not rely on SUV
                      thresholds, making it flexible and robust for clinical use.
                      The implementation of this system aims to improve
                      interdisciplinary communication, support longitudinal
                      follow-up, and facilitate future multicenter trials.
                      Conclusion: The proposed FAP-RADS version 1.0 is a
                      comprehensive and flexible framework that has the potential
                      to enhance the quality and consistency of FAP-targeted
                      imaging interpretation in clinical practice. Its application
                      may lead to better research outcomes, broader acceptance
                      within the oncologic community, and streamlined regulatory
                      processes related to FAP-based radiotracer approval.},
      keywords     = {FAP PET (Other) / FAP-RADS (Other) / FAP-targeted imaging
                      (Other) / FAPI (Other) / RADS framework (Other) /
                      standardized reporting (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40473461},
      doi          = {10.2967/jnumed.125.269914},
      url          = {https://inrepo02.dkfz.de/record/301886},
}