TY  - JOUR
AU  - Heider, Sina
AU  - Allwohn, Luisa
AU  - Rühle, Alexander
AU  - Ehret, Felix
AU  - Kaul, David
AU  - Oertel, Michael
AU  - Pepper, Niklas B
AU  - Hoffmann, Elgin
AU  - Bodensohn, Raphael
AU  - Ruder, Arne
AU  - Popp, Ilinca
AU  - Merten, Roland
AU  - Eich, Hans T
AU  - Bernhardt, Denise
AU  - Schneller, Folker
AU  - Schorb, Elisabeth
AU  - Wielenberg, Nanna
AU  - Combs, Stephanie E
AU  - Grosu, Anca L
AU  - Nicolay, Nils H
AU  - Seidel, Clemens
TI  - Comparison of survival and progression after focal- or whole brain radiotherapy in patients with primary CNS lymphoma - Results from a large multicenter analysis of the German Society of Radiation Oncology's Neuro-Radio-Oncology Working Group (DEGRO AG-NRO).
JO  - Radiotherapy and oncology
VL  - 209
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-01186
SP  - 110984
PY  - 2025
N1  - Volume 209, August 2025, 110984
AB  - Primary central nervous system lymphoma (PCNSL) is a rare but aggressive disease. The application of radiotherapy (RT) as part of treatment usually involved whole-brain radiotherapy (WBRT). Focal radiotherapy (fRT) might be locally active, but comparative outcome data is lacking.Data from a multicenter registry of the German Society of Radiation Oncology's Neuro-Radio-Oncology Working Group (DEGRO AG-NRO) was analyzed. Patients treated for PCNSL between 2007 and 2023 who received RT at any stage of their disease were included. Kaplan-Meier and Cox proportional hazards regression analyses were conducted to compare survival between focal (fRT) and whole-brain radiotherapy (WBRT).Survival data of 151 patients from eight centers were available. The median age at diagnosis was 66.5 years, and the median Eastern Cooperative Oncology Group Performance Status Scale (ECOG PS) was 2. Eighteen percent of patients (n = 27) received primary RT, 33 
KW  - Focal radiotherapy (Other)
KW  - PCNSL (Other)
KW  - Primary CNS lymphoma (Other)
KW  - Stereotactic radiotherapy (Other)
KW  - Whole brain irradiation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40490053
DO  - DOI:10.1016/j.radonc.2025.110984
UR  - https://inrepo02.dkfz.de/record/301916
ER  -