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@ARTICLE{Gaballa:301918,
      author       = {A. H. H. H. Gaballa$^*$ and B. Krenz and L. Uhl},
      title        = {{MYC}: {T}he {G}uardian of {I}ts {O}wn {C}haos.},
      journal      = {Bioessays},
      volume       = {47},
      number       = {7},
      issn         = {0265-9247},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2025-01188},
      pages        = {e70010},
      year         = {2025},
      note         = {2025 Jul;47(7):e70010},
      abstract     = {MYC proteins are potent oncoproteins that drive
                      tumorigenesis in a wide range of cancers, making it critical
                      to understand their oncogenic functions and underlying
                      mechanisms. Although MYC overexpression induces
                      transcriptional and replication-associated stress, recent
                      studies have paradoxically identified MYC as a key
                      resilience factor that protects cancer cells from these
                      stressors. In this review, we explore the dual role of MYC
                      in both driving and mitigating cellular stress to achieve
                      its oncogenic function. We also examine how MYC-induced
                      transcriptional and replicative stress generates potentially
                      immunogenic nucleic acid species while simultaneously
                      helping cancer cells evade host immune recognition. We
                      propose a model in which MYC plays a critical role in
                      managing the stress it induces, thereby maintaining a
                      balance that promotes tumor growth. Based on this model, we
                      discuss potential therapeutic strategies targeting
                      MYC-dependent stress responses, offering new avenues for
                      cancer treatment and highlighting the complexity of
                      MYC-driven oncogenesis.},
      subtyp        = {Review Article},
      keywords     = {Immune evasion (Other) / MYC (Other) / Replication stress
                      (Other) / Transcription stress (Other)},
      cin          = {MU01},
      ddc          = {540},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40488968},
      doi          = {10.1002/bies.70010},
      url          = {https://inrepo02.dkfz.de/record/301918},
}