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@ARTICLE{Dampmann:301923,
      author       = {M. Dampmann and B. von Tresckow$^*$ and H. C. Reinhardt$^*$
                      and R. Küppers$^*$ and J. von Tresckow},
      title        = {{I}nsights into the pathogenesis and biology of chronic
                      lymphocytic leukemia through analysis of its {B}-cell
                      receptor.},
      journal      = {Leukemia and lymphoma},
      volume       = {nn},
      issn         = {1026-8022},
      address      = {London [u.a.]},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {DKFZ-2025-01193},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {The B-cell antigen receptor (BCR) plays an essential role
                      in the pathogenesis of B-cell malignancies such as chronic
                      lymphocytic leukemia (CLL). CLL exhibits two main subtypes
                      based on immunoglobulin heavy chain variable (IGHV) region
                      mutational status: About half of the cases carry somatically
                      mutated immunoglobulin V genes and hence derive from
                      germinal center experienced memory B cells, whereas
                      unmutated CLL derives from (likely CD5-positive)
                      antigen-stimulated, but germinal center independent mature B
                      cells. CLL precursor cells can be found years before
                      diagnosis. The IGHV mutational status of CLL clones serves
                      as one of the strongest prognostic markers. CLL often
                      carries highly similar, i.e. stereotyped BCRs pointing to
                      recognition of a restricted set of antigens. Indeed, the
                      BCRs of many CLL clones are autoreactive for particular
                      autoantigens, including the BCR itself. Pathogenic antigens
                      are further drivers in CLL development. Thus, BCR-mediated
                      signaling and antigen recognition play a major role in CLL
                      pathogenesis.},
      subtyp        = {Review Article},
      keywords     = {Autoreactivity (Other) / B-cell receptor (Other) / chronic
                      lymphocytic leukemia (Other) / somatic hypermutation (Other)
                      / stereotypy (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40493712},
      doi          = {10.1080/10428194.2025.2513005},
      url          = {https://inrepo02.dkfz.de/record/301923},
}