%0 Journal Article
%A Sendker, Stephanie
%A Schneider, Markus
%A Antoniou, Evangelia
%A Neumann, Daniel
%A Niktoreh, Naghmeh
%A Dirksen, Uta
%A von Neuhoff, Nils
%A Creutzig, Ursula
%A Reinhardt, Dirk
%A Waack, Katharina
%T Improved outcomes and treatment guidance in pediatric therapy-related AML: AML-BFM study group recommendations.
%J Blood advances
%V 9
%N 11
%@ 2473-9529
%C Washington, DC
%I American Society of Hematology
%M DKFZ-2025-01194
%P 2831 - 2841
%D 2025
%X Therapy-related acute myeloid leukemia (AML; tAML) is one of the most feared therapy-emergent complications. This study aims to determine the clinical and pathological significance and define therapeutic implications and poor prognosticators in pediatric tAML. We analyzed a total of 119 pediatric patients (aged 2-20 years) who were centrally diagnosed with tAML within the Acute Myeloid Leukemia Berlin-Frankfurt-Münster (AML-BFM) study group between 1993 and 2019. Compared with de novo AML, tAML was associated with decreased white blood count and involvement of the central nervous system. Latency to tAML was inversely correlated with age at primary malignancy. Patients with tAML were more likely to have abnormal karyotypes, overrepresenting KMT2A rearrangements, the unfavorable cytogenetics -7/del(7q), as well as complex and monosomal karyotypes, whereas core-binding AML was underrepresented. The occurrence of stratification-relevant molecular genetics was comparable with de novo AML, whereas CEBPAdm was absent in tAML. Survival rates in tAML improved from 10
%K Humans
%K Child
%K Leukemia, Myeloid, Acute: therapy
%K Leukemia, Myeloid, Acute: etiology
%K Leukemia, Myeloid, Acute: mortality
%K Leukemia, Myeloid, Acute: diagnosis
%K Adolescent
%K Child, Preschool
%K Female
%K Male
%K Young Adult
%K Treatment Outcome
%K Prognosis
%K Neoplasms, Second Primary: therapy
%K Neoplasms, Second Primary: mortality
%K Neoplasms, Second Primary: diagnosis
%K Neoplasms, Second Primary: etiology
%K Disease Management
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39969195
%R 10.1182/bloodadvances.2024014728
%U https://inrepo02.dkfz.de/record/301924