TY  - JOUR
AU  - Krech, Maja
AU  - Muench, Amos
AU  - Teichmann, Daniel
AU  - Kuzman, Peter
AU  - Suwala, Abigail K
AU  - Ippen, Franziska M
AU  - Müther, Michael
AU  - Weber, Katharina
AU  - Wenger-Alakmeh, Katharina
AU  - Onken, Julia
AU  - Vajkoczy, Peter
AU  - Behling, Felix
AU  - May, Sven-Axel
AU  - Ntoulias, Georgios
AU  - Krauss, Joachim K
AU  - Atallah, Oday
AU  - Esmaeilzadeh, Majid
AU  - Mueller, Wolf C
AU  - Heppner, Frank L
AU  - Radbruch, Helena
AU  - Dittmayer, Carsten
AU  - Stenzel, Werner
AU  - Koch, Arend
AU  - Capper, David
AU  - Kaul, David
AU  - Paulus, Werner
AU  - Plate, Karl H
AU  - Steinbach, Joachim P
AU  - Czabanka, Markus
AU  - Beschorner, Rudi
AU  - von Deimling, Andreas
AU  - Bockmayr, Michael
AU  - Neumann, Julia E
AU  - Brandner, Sebastian
AU  - Krieger, Teresa
AU  - Hartmann, Christian
AU  - Thomas, Christian
AU  - Schweizer, Leonille
TI  - Outcome-associated factors in a molecularly defined cohort of central neurocytoma.
JO  - Acta neuropathologica
VL  - 149
IS  - 1
SN  - 0001-6322
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2025-01202
SP  - 61
PY  - 2025
AB  - Central neurocytomas (CN) are intraventricular brain tumors predominantly occurring in young adults. Although prognosis is usually favorable, tumor recurrence is common, particularly following subtotal resection (STR). Currently, the risk of progression is evaluated using atypical features and an elevated Ki67 proliferation index. However, these markers lack consistent definitions, raising the need for objective criteria. Genome-wide DNA methylation profiles were examined in 136 tumors histologically classified as CN. Clinical/histopathological characteristics were assessed in 93/90 cases, and whole-exome sequencing was conducted in 12 cases. Clinical and molecular characteristics were integrated into a survival model to predict progression-free survival (PFS). A diagnosis of CN was epigenetically confirmed in 125 of 136 cases (92
KW  - Humans
KW  - Male
KW  - Female
KW  - Neurocytoma: genetics
KW  - Neurocytoma: pathology
KW  - Adult
KW  - Young Adult
KW  - Brain Neoplasms: genetics
KW  - Brain Neoplasms: pathology
KW  - DNA Methylation
KW  - Middle Aged
KW  - Adolescent
KW  - Cohort Studies
KW  - Neoplasm Recurrence, Local: genetics
KW  - Prognosis
KW  - DNA methylation profiling (Other)
KW  - FGFR3 (Other)
KW  - Neurocytoma (Other)
KW  - Progression-free survival (Other)
KW  - Radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40498174
DO  - DOI:10.1007/s00401-025-02894-3
UR  - https://inrepo02.dkfz.de/record/302003
ER  -