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@ARTICLE{Zuljan:302013,
      author       = {E. Zuljan and B. von der Emde and I. Piwonski and A.
                      Pestana$^*$ and K. Klinghammer$^*$ and A. Mock$^*$ and P.
                      Horak$^*$ and C. Heining$^*$ and F. Klauschen$^*$ and I.
                      Pretzell$^*$ and M. Boerries$^*$ and C. H. Brandts$^*$ and
                      S. Kreutzfeldt$^*$ and M.-V. Teleanu$^*$ and D.
                      Hübschmann$^*$ and L. G. T. Morris and M. Heiland and U.
                      Keller$^*$ and T. Conrad and H. Glimm$^*$ and S.
                      Fröhling$^*$ and S. Ochsenreither$^*$ and U. Keilholz$^*$
                      and E. Blanc and D. Beule and D. Rieke$^*$},
      title        = {{A} macrophage-predominant immunosuppressive
                      microenvironment and therapeutic vulnerabilities in advanced
                      salivary gland cancer.},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2025-01211},
      pages        = {5303},
      year         = {2025},
      abstract     = {Salivary gland cancers are rare, diverse malignancies
                      characterized by poor response to immunotherapy. The tumor
                      immune environment in these cancers remains poorly
                      understood. To address this, we perform an integrative
                      analysis of the tumor immune microenvironment in a large
                      cohort of advanced salivary gland cancer samples. Most
                      tumors exhibit low immune activity with limited immune cell
                      infiltration. Inflammation is linked to higher tumor
                      mutational burden in non-adenoid cystic carcinoma
                      histologies. Subtype specific expression of immune
                      checkpoints is identified with prominent expression of VTCN1
                      in luminal-like cells within adenoid cystic carcinoma.
                      Macrophages with immunosuppressive properties dominate the
                      immune microenvironment across subtypes. Responses to
                      immunotherapy are limited and associated with a higher ratio
                      of T-cells relative to macrophages in individual cases,
                      warranting further investigation. Here, we show an
                      immunosuppressive environment in salivary gland cancers and
                      identify subtype-specific immune vulnerabilities that could
                      inform tailored therapeutic strategies.},
      keywords     = {Humans / Salivary Gland Neoplasms: immunology / Salivary
                      Gland Neoplasms: pathology / Salivary Gland Neoplasms:
                      genetics / Salivary Gland Neoplasms: therapy / Tumor
                      Microenvironment: immunology / Tumor Microenvironment:
                      genetics / Macrophages: immunology / Immunotherapy / Female
                      / Male / T-Lymphocytes: immunology / Carcinoma, Adenoid
                      Cystic: immunology / Carcinoma, Adenoid Cystic: pathology /
                      Carcinoma, Adenoid Cystic: genetics / Salivary Glands:
                      pathology / Salivary Glands: immunology / Middle Aged},
      cin          = {BE01 / B340 / HD01 / DD01 / MU01 / ED01 / FR01 / FM01},
      ddc          = {500},
      cid          = {I:(DE-He78)BE01-20160331 / I:(DE-He78)B340-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)DD01-20160331 /
                      I:(DE-He78)MU01-20160331 / I:(DE-He78)ED01-20160331 /
                      I:(DE-He78)FR01-20160331 / I:(DE-He78)FM01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40506428},
      doi          = {10.1038/s41467-025-60421-0},
      url          = {https://inrepo02.dkfz.de/record/302013},
}