TY  - JOUR
AU  - Corral, Juan E
AU  - Norwood, Dalton A
AU  - Alvarez, Christian S
AU  - Kim, Do Han
AU  - Montalvan-Sanchez, Eleazar E
AU  - Rivera-Andrade, Alvaro
AU  - Ramirez-Zea, Manuel
AU  - McGlynn, Katherine A
AU  - Waterboer, Tim
AU  - Dominguez, Ricardo L
AU  - Morgan, Douglas R
TI  - High Seroprevalence of Helicobacter pylori and CagA/VacA Virulence Factors in Northern Central America.
JO  - Gastroenterology research
VL  - 18
IS  - 3
SN  - 1918-2805
CY  - Quebec, Canada J5R 5Z3
PB  - [Verlag nicht ermittelbar]
M1  - DKFZ-2025-01215
SP  - 119 - 128
PY  - 2025
AB  - Northern Central America is unique in the Western Hemisphere, with a high incidence of gastric cancer, low/middle-income country (LMIC) status, and a substantial emigration to the United States. The two primary Helicobacter pylori (H. pylori) virulence factors related to carcinogenesis are cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA). The prevalence of these factors may help delineate gastric cancer risk in the region. We aimed to characterize the H. pylori seroprevalence and virulence factors in two Central American Countries (Honduras and Guatemala).Healthy volunteers from Western Honduras and Central-Western Guatemala were recruited and tested for antibodies against 13 H. pylori antigens using a novel multiplex serology assay. H. pylori seropositivity was defined as positivity for ≥ 4 antigens, and active infection was defined as positivity for a combination of 2/4 antigens: VacA, GroEl, HcpC, and HP1564, based upon the literature. Multivariate logistic regression models were used to estimate the odds ratios for the association between H. pylori and CagA positivity.A total of 1,143 healthy adults were tested using the H. pylori multiplex serology assay (444 in Guatemala and 699 in Honduras). Mean age was 54.2 ± 14.5 years, 46.2
KW  - CagA (Other)
KW  - Central America (Other)
KW  - Gastric cancer (Other)
KW  - Helicobacter pylori (Other)
KW  - VacA (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40503193
C2  - pmc:PMC12151123
DO  - DOI:10.14740/gr2036
UR  - https://inrepo02.dkfz.de/record/302017
ER  -