%0 Journal Article
%A Matta, Komodo
%A Viallon, Vivian
%A Chatziioannou, Anastasia Chrysovalantou
%A Robinot, Nivonirina
%A Wedekind, Roland
%A Dahm, Christina C
%A Rostgaard-Hansen, Agnetha Linn
%A Tjønneland, Anne
%A Truong, Therese
%A Marques, Chloé
%A Frenoy, Pauline
%A Kaaks, Rudolf
%A Fortner, Renée Turzanski
%A Schulze, Matthias B
%A Sieri, Sabrina
%A Fordellone, Mario
%A Tumino, Rosario
%A Ricceri, Fulvio
%A Braaten, Tonje
%A Nøst, Therese Haugdahl
%A Sánchez, Maria-Jose
%A Mokoroa-Carollo, Olatz
%A Colorado-Yohar, Sandra
%A Trobajo-Sanmartín, Camino
%A Papier, Keren
%A Harewood, Rhea
%A Tsilidis, Kostas
%A Vaccarella, Salvatore
%A Johansson, Mattias
%A Weiderpass, Elisabete
%A Delpierre, Cyrille
%A Lamy, Sebastien
%A Borch, Kristin Benjaminsen
%A Keski-Rahkonen, Pekka
%A Riboli, Elio
%A Freisling, Heinz
%A Gunter, Marc
%A Ferrari, Pietro
%T Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk?
%J Cancer & metabolism
%V 13
%N 1
%@ 2049-3002
%C London
%I Biomed Central
%M DKFZ-2025-01242
%P 30
%D 2025
%X Colon cancer is strongly influenced by lifestyle factors. Sociodemographic factors like sex and socioeconomic position (SEP) might modulate the relationship between lifestyle and colon cancer risk. Metabolomics offers potential to uncover biological mechanisms linking lifestyle and colon cancer.Lifestyle and untargeted metabolomic data were available from a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 1,067 colon cancer cases and 1,067 controls matched on age, sex, study centre, and blood collection time. Serum samples were analyzed using liquid chromatography-mass spectrometry. The Healthy Lifestyle Index (HLI) score was derived from smoking habits, alcohol intake, body mass index (BMI), physical activity, and diet. Penalised regression was applied in controls to derive metabolic signatures for the HLI and the lifestyle components. Associations of lifestyle factors and the metabolic signatures with colon cancer risk were estimated in conditional logistic regression models, overall and by sex and SEP.The HLI score was inversely associated with colon cancer risk, with an odds ratio (OR) per 1-standard deviation (SD) increment equal to 0.79; 95
%K Colon cancer (Other)
%K Healthy Lifestyle (Other)
%K LASSO regression (Other)
%K Sex (Other)
%K Socioeconomic position (Other)
%K Untargeted metabolomics (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40524238
%2 pmc:PMC12168339
%R 10.1186/s40170-025-00388-0
%U https://inrepo02.dkfz.de/record/302110