TY  - JOUR
AU  - Matta, Komodo
AU  - Viallon, Vivian
AU  - Chatziioannou, Anastasia Chrysovalantou
AU  - Robinot, Nivonirina
AU  - Wedekind, Roland
AU  - Dahm, Christina C
AU  - Rostgaard-Hansen, Agnetha Linn
AU  - Tjønneland, Anne
AU  - Truong, Therese
AU  - Marques, Chloé
AU  - Frenoy, Pauline
AU  - Kaaks, Rudolf
AU  - Fortner, Renée Turzanski
AU  - Schulze, Matthias B
AU  - Sieri, Sabrina
AU  - Fordellone, Mario
AU  - Tumino, Rosario
AU  - Ricceri, Fulvio
AU  - Braaten, Tonje
AU  - Nøst, Therese Haugdahl
AU  - Sánchez, Maria-Jose
AU  - Mokoroa-Carollo, Olatz
AU  - Colorado-Yohar, Sandra
AU  - Trobajo-Sanmartín, Camino
AU  - Papier, Keren
AU  - Harewood, Rhea
AU  - Tsilidis, Kostas
AU  - Vaccarella, Salvatore
AU  - Johansson, Mattias
AU  - Weiderpass, Elisabete
AU  - Delpierre, Cyrille
AU  - Lamy, Sebastien
AU  - Borch, Kristin Benjaminsen
AU  - Keski-Rahkonen, Pekka
AU  - Riboli, Elio
AU  - Freisling, Heinz
AU  - Gunter, Marc
AU  - Ferrari, Pietro
TI  - Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk?
JO  - Cancer & metabolism
VL  - 13
IS  - 1
SN  - 2049-3002
CY  - London
PB  - Biomed Central
M1  - DKFZ-2025-01242
SP  - 30
PY  - 2025
AB  - Colon cancer is strongly influenced by lifestyle factors. Sociodemographic factors like sex and socioeconomic position (SEP) might modulate the relationship between lifestyle and colon cancer risk. Metabolomics offers potential to uncover biological mechanisms linking lifestyle and colon cancer.Lifestyle and untargeted metabolomic data were available from a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 1,067 colon cancer cases and 1,067 controls matched on age, sex, study centre, and blood collection time. Serum samples were analyzed using liquid chromatography-mass spectrometry. The Healthy Lifestyle Index (HLI) score was derived from smoking habits, alcohol intake, body mass index (BMI), physical activity, and diet. Penalised regression was applied in controls to derive metabolic signatures for the HLI and the lifestyle components. Associations of lifestyle factors and the metabolic signatures with colon cancer risk were estimated in conditional logistic regression models, overall and by sex and SEP.The HLI score was inversely associated with colon cancer risk, with an odds ratio (OR) per 1-standard deviation (SD) increment equal to 0.79; 95
KW  - Colon cancer (Other)
KW  - Healthy Lifestyle (Other)
KW  - LASSO regression (Other)
KW  - Sex (Other)
KW  - Socioeconomic position (Other)
KW  - Untargeted metabolomics (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40524238
C2  - pmc:PMC12168339
DO  - DOI:10.1186/s40170-025-00388-0
UR  - https://inrepo02.dkfz.de/record/302110
ER  -