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@ARTICLE{Matta:302110,
      author       = {K. Matta and V. Viallon and A. C. Chatziioannou and N.
                      Robinot and R. Wedekind and C. C. Dahm and A. L.
                      Rostgaard-Hansen and A. Tjønneland and T. Truong and C.
                      Marques and P. Frenoy and R. Kaaks$^*$ and R. T. Fortner$^*$
                      and M. B. Schulze and S. Sieri and M. Fordellone and R.
                      Tumino and F. Ricceri and T. Braaten and T. H. Nøst and
                      M.-J. Sánchez and O. Mokoroa-Carollo and S. Colorado-Yohar
                      and C. Trobajo-Sanmartín and K. Papier and R. Harewood and
                      K. Tsilidis and S. Vaccarella and M. Johansson and E.
                      Weiderpass and C. Delpierre and S. Lamy and K. B. Borch and
                      P. Keski-Rahkonen and E. Riboli and H. Freisling and M.
                      Gunter and P. Ferrari},
      title        = {{C}an serum metabolic signatures inform on the relationship
                      between healthy lifestyle and colon cancer risk?},
      journal      = {Cancer $\&$ metabolism},
      volume       = {13},
      number       = {1},
      issn         = {2049-3002},
      address      = {London},
      publisher    = {Biomed Central},
      reportid     = {DKFZ-2025-01242},
      pages        = {30},
      year         = {2025},
      abstract     = {Colon cancer is strongly influenced by lifestyle factors.
                      Sociodemographic factors like sex and socioeconomic position
                      (SEP) might modulate the relationship between lifestyle and
                      colon cancer risk. Metabolomics offers potential to uncover
                      biological mechanisms linking lifestyle and colon
                      cancer.Lifestyle and untargeted metabolomic data were
                      available from a nested case-control study within the
                      European Prospective Investigation into Cancer and Nutrition
                      (EPIC), including 1,067 colon cancer cases and 1,067
                      controls matched on age, sex, study centre, and blood
                      collection time. Serum samples were analyzed using liquid
                      chromatography-mass spectrometry. The Healthy Lifestyle
                      Index (HLI) score was derived from smoking habits, alcohol
                      intake, body mass index (BMI), physical activity, and diet.
                      Penalised regression was applied in controls to derive
                      metabolic signatures for the HLI and the lifestyle
                      components. Associations of lifestyle factors and the
                      metabolic signatures with colon cancer risk were estimated
                      in conditional logistic regression models, overall and by
                      sex and SEP.The HLI score was inversely associated with
                      colon cancer risk, with an odds ratio (OR) per 1-standard
                      deviation (SD) increment equal to 0.79; $95\%$ CI: 0.71,
                      0.87. The metabolic signature of HLI, comprising 130
                      features, was moderately correlated with HLI (r = 0.59;
                      $94\%$ CI: 0.56, 0.61), and was inversely associated with
                      colon cancer risk (OR = 0.86; $95\%$ CI: 0.78, 0.95). After
                      adjustment for the HLI score, the association of the
                      metabolic signature of HLI and colon cancer risk was null
                      (OR = 1.00, $95\%$ CI 0.88, 1.13). Associations of lifestyle
                      factors and the metabolic signature with colon cancer risk
                      were consistently stronger for men than for women and did
                      not differ by SEP.In this study across seven European
                      countries, healthy lifestyle was inversely associated with
                      colon cancer risk, with stronger associations in men than
                      women and no differences across SEP. However, the serum
                      metabolic signatures after adjustment for lifestyle factors
                      were not found to be associated with colon cancer risk,
                      suggesting that lifestyle impacts colon cancer through
                      mechanisms not captured by the signatures.},
      keywords     = {Colon cancer (Other) / Healthy Lifestyle (Other) / LASSO
                      regression (Other) / Sex (Other) / Socioeconomic position
                      (Other) / Untargeted metabolomics (Other)},
      cin          = {C020 / C180},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C180-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40524238},
      pmc          = {pmc:PMC12168339},
      doi          = {10.1186/s40170-025-00388-0},
      url          = {https://inrepo02.dkfz.de/record/302110},
}