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@ARTICLE{Imle:302111,
      author       = {R. Imle$^*$ and D. Blösel$^*$ and F. K. Kommoss$^*$ and S.
                      Placke$^*$ and E. Stutheit-Zhao$^*$ and C. Blume$^*$ and D.
                      Lupar$^*$ and L. Schmitt$^*$ and C. Winter$^*$ and L.
                      Wagner$^*$ and M. von Eicke$^*$ and H. Walzer$^*$ and J.
                      Förderer$^*$ and S. Laier$^*$ and M. Hertwig$^*$ and H.
                      Peterziel$^*$ and I. Oehme$^*$ and S. Scheuerman$^*$ and C.
                      Seitz$^*$ and F. H. Geyer$^*$ and F. Cidre-Aranaz$^*$ and T.
                      Grünewald$^*$ and C. Vokuhl and P. Chudasama$^*$ and C.
                      Scholl$^*$ and C. Schmidt$^*$ and P. Günther and M.
                      Sill$^*$ and K. B. Jones and S. Pfister$^*$ and R. Autry$^*$
                      and A. Banito$^*$},
      title        = {{S}omatic gene delivery faithfully recapitulates a
                      molecular spectrum of high-risk sarcomas.},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2025-01243},
      pages        = {5283},
      year         = {2025},
      note         = {DKFZ-ZMBH Alliance / #EA:B380#LA:B380#},
      abstract     = {A major challenge hampering therapeutic advancements for
                      high-risk sarcoma patients is the broad spectrum of
                      molecularly distinct sarcoma types and the corresponding
                      lack of suitable model systems. Here we describe the
                      development of a genetically-controlled, yet versatile mouse
                      modeling platform allowing delivery of different genetic
                      lesions by muscle electroporation (EPO) in wildtype mice.
                      This EPO-GEMM (EPO-based genetically engineered mouse model)
                      platform allows the generation of ten genetically distinct
                      sarcomas on an isogenic background, including the first
                      model of ETV6::NTRK3-driven sarcoma. Comprehensive
                      histological and molecular profiling reveals that this mouse
                      sarcoma cohort recapitulates a spectrum of molecularly
                      diverse sarcomas with gene fusions acting as major
                      determinants of sarcoma biology. Integrative cross-species
                      analyses show faithful recapitulation of human sarcoma
                      subtypes, including expression of relevant immunotherapy
                      targets. Comparison of syngeneic allografting methods
                      enables reliable preservation and scalability of
                      sarcoma-EPO-GEMMs for preclinical treatment trials, such as
                      NTRK inhibitor therapy in an immunocompetent background.},
      keywords     = {Animals / Sarcoma: genetics / Sarcoma: pathology / Mice /
                      Humans / Disease Models, Animal / Gene Transfer Techniques /
                      Electroporation: methods / Mice, Transgenic / Female / Mice,
                      Inbred C57BL},
      cin          = {B380 / B062 / HD01 / B300 / W420 / A190 / B310 / B410 /
                      B390 / B290 / W210},
      ddc          = {500},
      cid          = {I:(DE-He78)B380-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)B300-20160331 /
                      I:(DE-He78)W420-20160331 / I:(DE-He78)A190-20160331 /
                      I:(DE-He78)B310-20160331 / I:(DE-He78)B410-20160331 /
                      I:(DE-He78)B390-20160331 / I:(DE-He78)B290-20160331 /
                      I:(DE-He78)W210-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40523919},
      pmc          = {pmc:PMC12170903},
      doi          = {10.1038/s41467-025-60519-5},
      url          = {https://inrepo02.dkfz.de/record/302111},
}