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000302149 1001_ $$0P:(DE-He78)87203aa70041809147d890af47404e46$$aWieser, Janine$$b0$$eFirst author$$udkfz
000302149 245__ $$aAssociations of Alcohol Use and Smoking With Early-Onset Colorectal Cancer-A Systematic Review and Meta-Analysis.
000302149 260__ $$aNew York, NY [u.a.]$$bElsevier$$c2025
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000302149 520__ $$aThe incidence of early-onset CRC (EOCRC) has lately been increasing. We aimed to synthesize findings on the association of smoking and alcohol consumption with EOCRC in a systematic review and meta-analysis. Following preregistration of the study protocol in PROSPERO (CRD42023424149), we searched PubMed and Web of Science for observational studies on the association of smoking or alcohol consumption with EOCRC. We performed meta-analyses, including several subgroup analyses, to examine the association of alcohol consumption and smoking, respectively, with the risk of EOCRC. Generally, random effects models were calculated, with fixed effect models employed for analyses including only a small number of studies. We included eleven studies for alcohol consumption and twelve for smoking. Alcohol use was found to be a risk factor for EOCRC, with a pooled odds ratio (OR) of 1.39 (95 % confidence interval (CI) 1.14-1.69). A dose-response model revealed a positive association between the amount of ethanol consumed and the risk of EOCRC (OR per 10 g/d ethanol increase 1.02, 95 % CI, 1.01-1.08). Smoking (ever or current combined) was also found to be a significant risk factor for EOCRC (OR 1.39, 95 % CI, 1.20-1.59). Alcohol consumption and smoking are significant risk factors for EOCRC and should be addressed in the context of prevention.
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000302149 650_7 $$2Other$$aAlcohol consumption
000302149 650_7 $$2Other$$aEpidemiology
000302149 650_7 $$2Other$$aLifestyle-related risk factors
000302149 650_7 $$2Other$$aModifiable risk factors
000302149 650_7 $$2Other$$aYoung adults
000302149 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b1$$udkfz
000302149 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b2$$udkfz
000302149 7001_ $$0P:(DE-He78)1b59582b6c05ac4e57aa8b90dd9667f9$$aMons, Ute$$b3$$eLast author$$udkfz
000302149 773__ $$0PERI:(DE-600)2572502-6$$a10.1016/j.clcc.2025.05.002$$gp. S1533002825000519$$n3$$p331-340.e15$$tClinical colorectal cancer and other gastrointestinal malignancies$$v24$$x1533-0028$$y2025
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