TY  - JOUR
AU  - Wieser, Janine
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
AU  - Mons, Ute
TI  - Associations of Alcohol Use and Smoking With Early-Onset Colorectal Cancer-A Systematic Review and Meta-Analysis.
JO  - Clinical colorectal cancer and other gastrointestinal malignancies
VL  - 24
IS  - 3
SN  - 1533-0028
CY  - New York, NY [u.a.]
PB  - Elsevier
M1  - DKFZ-2025-01267
SP  - 331-340.e15
PY  - 2025
N1  - #EA:C120#LA:C120# / 2025 Sep;24(3):331-340.e15
AB  - The incidence of early-onset CRC (EOCRC) has lately been increasing. We aimed to synthesize findings on the association of smoking and alcohol consumption with EOCRC in a systematic review and meta-analysis. Following preregistration of the study protocol in PROSPERO (CRD42023424149), we searched PubMed and Web of Science for observational studies on the association of smoking or alcohol consumption with EOCRC. We performed meta-analyses, including several subgroup analyses, to examine the association of alcohol consumption and smoking, respectively, with the risk of EOCRC. Generally, random effects models were calculated, with fixed effect models employed for analyses including only a small number of studies. We included eleven studies for alcohol consumption and twelve for smoking. Alcohol use was found to be a risk factor for EOCRC, with a pooled odds ratio (OR) of 1.39 (95 
KW  - Alcohol consumption (Other)
KW  - Epidemiology (Other)
KW  - Lifestyle-related risk factors (Other)
KW  - Modifiable risk factors (Other)
KW  - Young adults (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40544033
DO  - DOI:10.1016/j.clcc.2025.05.002
UR  - https://inrepo02.dkfz.de/record/302149
ER  -