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@ARTICLE{Wieser:302149,
      author       = {J. Wieser$^*$ and M. Hoffmeister$^*$ and H. Brenner$^*$ and
                      U. Mons$^*$},
      title        = {{A}ssociations of {A}lcohol {U}se and {S}moking {W}ith
                      {E}arly-{O}nset {C}olorectal {C}ancer-{A} {S}ystematic
                      {R}eview and {M}eta-{A}nalysis.},
      journal      = {Clinical colorectal cancer and other gastrointestinal
                      malignancies},
      volume       = {24},
      number       = {3},
      issn         = {1533-0028},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-01267},
      pages        = {331-340.e15},
      year         = {2025},
      note         = {#EA:C120#LA:C120# / 2025 Sep;24(3):331-340.e15},
      abstract     = {The incidence of early-onset CRC (EOCRC) has lately been
                      increasing. We aimed to synthesize findings on the
                      association of smoking and alcohol consumption with EOCRC in
                      a systematic review and meta-analysis. Following
                      preregistration of the study protocol in PROSPERO
                      (CRD42023424149), we searched PubMed and Web of Science for
                      observational studies on the association of smoking or
                      alcohol consumption with EOCRC. We performed meta-analyses,
                      including several subgroup analyses, to examine the
                      association of alcohol consumption and smoking,
                      respectively, with the risk of EOCRC. Generally, random
                      effects models were calculated, with fixed effect models
                      employed for analyses including only a small number of
                      studies. We included eleven studies for alcohol consumption
                      and twelve for smoking. Alcohol use was found to be a risk
                      factor for EOCRC, with a pooled odds ratio (OR) of 1.39 (95
                      $\%$ confidence interval (CI) 1.14-1.69). A dose-response
                      model revealed a positive association between the amount of
                      ethanol consumed and the risk of EOCRC (OR per 10 g/d
                      ethanol increase 1.02, 95 $\%$ CI, 1.01-1.08). Smoking (ever
                      or current combined) was also found to be a significant risk
                      factor for EOCRC (OR 1.39, 95 $\%$ CI, 1.20-1.59). Alcohol
                      consumption and smoking are significant risk factors for
                      EOCRC and should be addressed in the context of prevention.},
      subtyp        = {Review Article},
      keywords     = {Alcohol consumption (Other) / Epidemiology (Other) /
                      Lifestyle-related risk factors (Other) / Modifiable risk
                      factors (Other) / Young adults (Other)},
      cin          = {C120 / C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40544033},
      doi          = {10.1016/j.clcc.2025.05.002},
      url          = {https://inrepo02.dkfz.de/record/302149},
}