000302263 001__ 302263
000302263 005__ 20250629021242.0
000302263 0247_ $$2doi$$a10.1038/s41467-025-60910-2
000302263 0247_ $$2pmid$$apmid:40562785
000302263 0247_ $$2altmetric$$aaltmetric:178346734
000302263 037__ $$aDKFZ-2025-01289
000302263 041__ $$aEnglish
000302263 082__ $$a500
000302263 1001_ $$aHasan, Sana S$$b0
000302263 245__ $$aObesity drives depot-specific vascular remodeling in male white adipose tissue.
000302263 260__ $$a[London]$$bSpringer Nature$$c2025
000302263 3367_ $$2DRIVER$$aarticle
000302263 3367_ $$2DataCite$$aOutput Types/Journal article
000302263 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1750941936_1470
000302263 3367_ $$2BibTeX$$aARTICLE
000302263 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000302263 3367_ $$00$$2EndNote$$aJournal Article
000302263 500__ $$aDivision Vascular Signaling and Cancer
000302263 520__ $$aObesity-driven pathological expansion of white adipose tissue (WAT) is a key driver of endothelial dysfunction. However, early vascular alterations associated with over-nutrition also serve to exacerbate WAT dysfunction. Here, we conduct a single-cell transcriptomic analysis of WAT endothelium to delineate endothelial heterogeneity and elucidate vascular alterations and its consequence in a male murine model of obesity. We demarcate depot-specific differences in subcutaneous (sWAT) and visceral WAT (vWAT) endothelium through in sillico analysis and further corroboration of our findings. Moreover, we identify a sWAT-specific fenestrated endothelial cell (EC) subtype, which declines in obese conditions. Utilizing systemic anti-VEGFA blockade and genetic Vegfa manipulation, we demonstrate that VEGFA is necessary for maintaining fenestration in sWAT. Additionally, we detect this fenestrated EC subtype in male human WAT, which undergoes reduction in individuals with obesity. Collectively, this atlas serves as a valuable tool for future studies to decipher the functional significance of different WAT EC subtypes.
000302263 536__ $$0G:(DE-HGF)POF4-311$$a311 - Zellbiologie und Tumorbiologie (POF4-311)$$cPOF4-311$$fPOF IV$$x0
000302263 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000302263 650_7 $$2NLM Chemicals$$aVascular Endothelial Growth Factor A
000302263 650_2 $$2MeSH$$aAnimals
000302263 650_2 $$2MeSH$$aMale
000302263 650_2 $$2MeSH$$aObesity: metabolism
000302263 650_2 $$2MeSH$$aObesity: pathology
000302263 650_2 $$2MeSH$$aObesity: genetics
000302263 650_2 $$2MeSH$$aAdipose Tissue, White: metabolism
000302263 650_2 $$2MeSH$$aAdipose Tissue, White: pathology
000302263 650_2 $$2MeSH$$aAdipose Tissue, White: blood supply
000302263 650_2 $$2MeSH$$aMice
000302263 650_2 $$2MeSH$$aVascular Remodeling: genetics
000302263 650_2 $$2MeSH$$aVascular Remodeling: physiology
000302263 650_2 $$2MeSH$$aHumans
000302263 650_2 $$2MeSH$$aEndothelial Cells: metabolism
000302263 650_2 $$2MeSH$$aEndothelial Cells: pathology
000302263 650_2 $$2MeSH$$aVascular Endothelial Growth Factor A: metabolism
000302263 650_2 $$2MeSH$$aVascular Endothelial Growth Factor A: genetics
000302263 650_2 $$2MeSH$$aVascular Endothelial Growth Factor A: antagonists & inhibitors
000302263 650_2 $$2MeSH$$aMice, Inbred C57BL
000302263 650_2 $$2MeSH$$aSubcutaneous Fat: metabolism
000302263 650_2 $$2MeSH$$aSubcutaneous Fat: pathology
000302263 650_2 $$2MeSH$$aSubcutaneous Fat: blood supply
000302263 650_2 $$2MeSH$$aSingle-Cell Analysis
000302263 650_2 $$2MeSH$$aDisease Models, Animal
000302263 650_2 $$2MeSH$$aIntra-Abdominal Fat: metabolism
000302263 650_2 $$2MeSH$$aEndothelium, Vascular: metabolism
000302263 650_2 $$2MeSH$$aEndothelium, Vascular: pathology
000302263 7001_ $$00000-0003-3217-5449$$aJohn, David$$b1
000302263 7001_ $$00000-0002-7863-5044$$aRudnicki, Martina$$b2
000302263 7001_ $$00000-0001-6677-4365$$aAlZaim, Ibrahim$$b3
000302263 7001_ $$aEberhard, Daniel$$b4
000302263 7001_ $$0P:(DE-He78)68d90eb013f51c689f9ebea83a920858$$aMoll, Iris$$b5
000302263 7001_ $$0P:(DE-He78)df29352b13734f9202e3b900aeef7754$$aTaylor, Jacqueline$$b6
000302263 7001_ $$00000-0001-7594-7280$$aKlein, Christian$$b7
000302263 7001_ $$avon Heesen, Maximilian$$b8
000302263 7001_ $$aConradi, Lena-Christin$$b9
000302263 7001_ $$00000-0003-3031-7677$$aAdams, Ralf H$$b10
000302263 7001_ $$00000-0002-9844-8000$$aLammert, Eckhard$$b11
000302263 7001_ $$00000-0003-4887-7672$$aKalucka, Joanna$$b12
000302263 7001_ $$00000-0002-3212-9381$$aRuhrberg, Christiana$$b13
000302263 7001_ $$00000-0002-1045-2436$$aDimmeler, Stefanie$$b14
000302263 7001_ $$aFischer, Andreas$$b15
000302263 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-60910-2$$gVol. 16, no. 1, p. 5392$$n1$$p5392$$tNature Communications$$v16$$x2041-1723$$y2025
000302263 909CO $$ooai:inrepo02.dkfz.de:302263$$pVDB
000302263 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)68d90eb013f51c689f9ebea83a920858$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000302263 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)df29352b13734f9202e3b900aeef7754$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000302263 9131_ $$0G:(DE-HGF)POF4-311$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vZellbiologie und Tumorbiologie$$x0
000302263 9141_ $$y2025
000302263 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2022$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-01-30T07:48:07Z
000302263 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-01-30T07:48:07Z
000302263 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review$$d2024-01-30T07:48:07Z
000302263 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2024-01-30T07:48:07Z
000302263 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bNAT COMMUN : 2022$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2025-01-02
000302263 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2025-01-02
000302263 9201_ $$0I:(DE-He78)A270-20160331$$kA270$$lVaskuläre Signaltransduktion und Krebs$$x0
000302263 980__ $$ajournal
000302263 980__ $$aVDB
000302263 980__ $$aI:(DE-He78)A270-20160331
000302263 980__ $$aUNRESTRICTED