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@ARTICLE{Offringa:302272,
      author       = {R. Offringa$^*$ and Z. B. Meng$^*$ and H. K. Cai and X. Y.
                      Shi and H. Mei and H. S. Wu},
      title        = {[{I}mplementation of personalized {T}-cell therapy in the
                      treatment of pancreatic cancer].},
      journal      = {Zhong hua wai ke za zhi},
      volume       = {63},
      number       = {8},
      issn         = {0529-5815},
      address      = {Bei jing shi},
      publisher    = {[Verlag nicht ermittelbar]},
      reportid     = {DKFZ-2025-01298},
      pages        = {666-671},
      year         = {2025},
      note         = {ISSN 0529-5815 / #EA:D200# / Article in Chinese},
      abstract     = {Pancreatic ductal adenocarcinoma is profoundly
                      treatment-resistant, due to intrinsic properties of the
                      tumor cells and the complex tumor microenvironment.
                      Consequently, surgical resection of the primary tumor is
                      still the only intervention that significantly prolongs
                      patient survival. This points at an urgent need for more
                      effective (neo)adjuvant strategies to increase the fraction
                      of patients eligible to surgery and to counter post-surgery
                      disease recurrence. The advent of single-cell RNA-sequencing
                      has created an opportunity for the development of a highly
                      potent, patient-tailored adjuvant treatment that is based on
                      the infusion of genetically engineered autologous T-cells
                      armed with tumor-reactive T-cell receptors as identified in
                      the patient's own tumor sample.},
      subtyp        = {Review Article},
      cin          = {D200},
      ddc          = {610},
      cid          = {I:(DE-He78)D200-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40556393},
      doi          = {DOI:10.3760/cma.j.cn112139-20250328-00164},
      url          = {https://inrepo02.dkfz.de/record/302272},
}