000302330 001__ 302330 000302330 005__ 20250630113839.0 000302330 0247_ $$2doi$$a10.3390/nu17121970 000302330 0247_ $$2pmid$$apmid:40573081 000302330 037__ $$aDKFZ-2025-01325 000302330 041__ $$aEnglish 000302330 082__ $$a610 000302330 1001_ $$00000-0003-2491-5099$$aPark, Jin Young$$b0 000302330 245__ $$aAssociation Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition. 000302330 260__ $$aBasel$$bMDPI$$c2025 000302330 3367_ $$2DRIVER$$aarticle 000302330 3367_ $$2DataCite$$aOutput Types/Journal article 000302330 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1751273292_21722 000302330 3367_ $$2BibTeX$$aARTICLE 000302330 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000302330 3367_ $$00$$2EndNote$$aJournal Article 000302330 520__ $$aBackground/Objectives: We examined the association between dietary intake and blood concentrations of one-carbon metabolism (OCM)-related nutrients in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Blood concentrations and dietary intake of the vitamins riboflavin (B2), Pyridoxal 5'-phosphate (PLP and B6), folate (B9), B12, and methionine, concentrations of homocysteine, and dietary intake of betaine, choline, and cysteine were pooled from 16,267 participants in nine EPIC nested case-control studies. Correlation analyses between dietary intakes and blood concentrations were carried out. Principal component (PC) analysis identified latent factors in the two sets of measurements. Results: Pearson correlations between dietary intakes and blood concentrations ranged from 0.08 for methionine to 0.12 for vitamin B2, 0.15 for vitamin B12, 0.17 for vitamin B6, and 0.19 for folate. Individual dietary intakes showed higher correlations (ranging from -0.14 to 0.82) compared to individual blood concentrations (from -0.31 to 0.29). Correlations did not vary by smoking status, case-control status, or vitamin supplement use. The first PC of dietary intakes was mostly associated with methionine, vitamin B12, cysteine, and choline, while the first PC of blood concentrations was associated with folate and vitamin B6. Conclusions: Within this large European study, we found weak to moderate associations between dietary intakes and concentrations of OCM-related nutrients. 000302330 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0 000302330 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de 000302330 650_7 $$2Other$$aEPIC 000302330 650_7 $$2Other$$ablood B-vitamin concentrations 000302330 650_7 $$2Other$$adietary B-vitamins 000302330 650_7 $$2Other$$anutrients 000302330 650_7 $$2Other$$aone-carbon metabolism 000302330 650_7 $$2Other$$apartial least square path modeling 000302330 650_7 $$2Other$$aprincipal component analysis 000302330 650_7 $$0935E97BOY8$$2NLM Chemicals$$aFolic Acid 000302330 650_7 $$0TLM2976OFR$$2NLM Chemicals$$aRiboflavin 000302330 650_7 $$0AE28F7PNPL$$2NLM Chemicals$$aMethionine 000302330 650_7 $$0P6YC3EG204$$2NLM Chemicals$$aVitamin B 12 000302330 650_7 $$08059-24-3$$2NLM Chemicals$$aVitamin B 6 000302330 650_7 $$0N91BDP6H0X$$2NLM Chemicals$$aCholine 000302330 650_7 $$03SCV180C9W$$2NLM Chemicals$$aBetaine 000302330 650_7 $$00LVT1QZ0BA$$2NLM Chemicals$$aHomocysteine 000302330 650_7 $$05V5IOJ8338$$2NLM Chemicals$$aPyridoxal Phosphate 000302330 650_7 $$07440-44-0$$2NLM Chemicals$$aCarbon 000302330 650_7 $$0K848JZ4886$$2NLM Chemicals$$aCysteine 000302330 650_2 $$2MeSH$$aHumans 000302330 650_2 $$2MeSH$$aMale 000302330 650_2 $$2MeSH$$aFemale 000302330 650_2 $$2MeSH$$aProspective Studies 000302330 650_2 $$2MeSH$$aMiddle Aged 000302330 650_2 $$2MeSH$$aDiet 000302330 650_2 $$2MeSH$$aEurope 000302330 650_2 $$2MeSH$$aFolic Acid: blood 000302330 650_2 $$2MeSH$$aRiboflavin: blood 000302330 650_2 $$2MeSH$$aMethionine: blood 000302330 650_2 $$2MeSH$$aVitamin B 12: blood 000302330 650_2 $$2MeSH$$aVitamin B 6: blood 000302330 650_2 $$2MeSH$$aCase-Control Studies 000302330 650_2 $$2MeSH$$aAged 000302330 650_2 $$2MeSH$$aCholine: blood 000302330 650_2 $$2MeSH$$aCholine: administration & dosage 000302330 650_2 $$2MeSH$$aBetaine: blood 000302330 650_2 $$2MeSH$$aBetaine: administration & dosage 000302330 650_2 $$2MeSH$$aNutrients: blood 000302330 650_2 $$2MeSH$$aHomocysteine: blood 000302330 650_2 $$2MeSH$$aPyridoxal Phosphate: blood 000302330 650_2 $$2MeSH$$aCarbon: metabolism 000302330 650_2 $$2MeSH$$aNeoplasms: blood 000302330 650_2 $$2MeSH$$aNutritional Status 000302330 650_2 $$2MeSH$$aCysteine: blood 000302330 650_2 $$2MeSH$$aCysteine: administration & dosage 000302330 650_2 $$2MeSH$$aAdult 000302330 7001_ $$aVan Puyvelde, Heleen$$b1 000302330 7001_ $$aRegazzetti, Lea$$b2 000302330 7001_ $$00000-0003-4231-5740$$aClasen, Joanna L$$b3 000302330 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b4 000302330 7001_ $$00000-0003-0559-6838$$aEussen, Simone$$b5 000302330 7001_ $$aUeland, Per Magne$$b6 000302330 7001_ $$aJohansson, Mattias$$b7 000302330 7001_ $$aBiessy, Carine$$b8 000302330 7001_ $$00000-0002-6236-6804$$aZamora-Ros, Raul$$b9 000302330 7001_ 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