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000302330 0247_ $$2doi$$a10.3390/nu17121970
000302330 0247_ $$2pmid$$apmid:40573081
000302330 037__ $$aDKFZ-2025-01325
000302330 041__ $$aEnglish
000302330 082__ $$a610
000302330 1001_ $$00000-0003-2491-5099$$aPark, Jin Young$$b0
000302330 245__ $$aAssociation Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition.
000302330 260__ $$aBasel$$bMDPI$$c2025
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000302330 520__ $$aBackground/Objectives: We examined the association between dietary intake and blood concentrations of one-carbon metabolism (OCM)-related nutrients in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Blood concentrations and dietary intake of the vitamins riboflavin (B2), Pyridoxal 5'-phosphate (PLP and B6), folate (B9), B12, and methionine, concentrations of homocysteine, and dietary intake of betaine, choline, and cysteine were pooled from 16,267 participants in nine EPIC nested case-control studies. Correlation analyses between dietary intakes and blood concentrations were carried out. Principal component (PC) analysis identified latent factors in the two sets of measurements. Results: Pearson correlations between dietary intakes and blood concentrations ranged from 0.08 for methionine to 0.12 for vitamin B2, 0.15 for vitamin B12, 0.17 for vitamin B6, and 0.19 for folate. Individual dietary intakes showed higher correlations (ranging from -0.14 to 0.82) compared to individual blood concentrations (from -0.31 to 0.29). Correlations did not vary by smoking status, case-control status, or vitamin supplement use. The first PC of dietary intakes was mostly associated with methionine, vitamin B12, cysteine, and choline, while the first PC of blood concentrations was associated with folate and vitamin B6. Conclusions: Within this large European study, we found weak to moderate associations between dietary intakes and concentrations of OCM-related nutrients.
000302330 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
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000302330 650_7 $$2Other$$aEPIC
000302330 650_7 $$2Other$$ablood B-vitamin concentrations
000302330 650_7 $$2Other$$adietary B-vitamins
000302330 650_7 $$2Other$$anutrients
000302330 650_7 $$2Other$$aone-carbon metabolism
000302330 650_7 $$2Other$$apartial least square path modeling
000302330 650_7 $$2Other$$aprincipal component analysis
000302330 650_7 $$0935E97BOY8$$2NLM Chemicals$$aFolic Acid
000302330 650_7 $$0TLM2976OFR$$2NLM Chemicals$$aRiboflavin
000302330 650_7 $$0AE28F7PNPL$$2NLM Chemicals$$aMethionine
000302330 650_7 $$0P6YC3EG204$$2NLM Chemicals$$aVitamin B 12
000302330 650_7 $$08059-24-3$$2NLM Chemicals$$aVitamin B 6
000302330 650_7 $$0N91BDP6H0X$$2NLM Chemicals$$aCholine
000302330 650_7 $$03SCV180C9W$$2NLM Chemicals$$aBetaine
000302330 650_7 $$00LVT1QZ0BA$$2NLM Chemicals$$aHomocysteine
000302330 650_7 $$05V5IOJ8338$$2NLM Chemicals$$aPyridoxal Phosphate
000302330 650_7 $$07440-44-0$$2NLM Chemicals$$aCarbon
000302330 650_7 $$0K848JZ4886$$2NLM Chemicals$$aCysteine
000302330 650_2 $$2MeSH$$aHumans
000302330 650_2 $$2MeSH$$aMale
000302330 650_2 $$2MeSH$$aFemale
000302330 650_2 $$2MeSH$$aProspective Studies
000302330 650_2 $$2MeSH$$aMiddle Aged
000302330 650_2 $$2MeSH$$aDiet
000302330 650_2 $$2MeSH$$aEurope
000302330 650_2 $$2MeSH$$aFolic Acid: blood
000302330 650_2 $$2MeSH$$aRiboflavin: blood
000302330 650_2 $$2MeSH$$aMethionine: blood
000302330 650_2 $$2MeSH$$aVitamin B 12: blood
000302330 650_2 $$2MeSH$$aVitamin B 6: blood
000302330 650_2 $$2MeSH$$aCase-Control Studies
000302330 650_2 $$2MeSH$$aAged
000302330 650_2 $$2MeSH$$aCholine: blood
000302330 650_2 $$2MeSH$$aCholine: administration & dosage
000302330 650_2 $$2MeSH$$aBetaine: blood
000302330 650_2 $$2MeSH$$aBetaine: administration & dosage
000302330 650_2 $$2MeSH$$aNutrients: blood
000302330 650_2 $$2MeSH$$aHomocysteine: blood
000302330 650_2 $$2MeSH$$aPyridoxal Phosphate: blood
000302330 650_2 $$2MeSH$$aCarbon: metabolism
000302330 650_2 $$2MeSH$$aNeoplasms: blood
000302330 650_2 $$2MeSH$$aNutritional Status
000302330 650_2 $$2MeSH$$aCysteine: blood
000302330 650_2 $$2MeSH$$aCysteine: administration & dosage
000302330 650_2 $$2MeSH$$aAdult
000302330 7001_ $$aVan Puyvelde, Heleen$$b1
000302330 7001_ $$aRegazzetti, Lea$$b2
000302330 7001_ $$00000-0003-4231-5740$$aClasen, Joanna L$$b3
000302330 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b4
000302330 7001_ $$00000-0003-0559-6838$$aEussen, Simone$$b5
000302330 7001_ $$aUeland, Per Magne$$b6
000302330 7001_ $$aJohansson, Mattias$$b7
000302330 7001_ $$aBiessy, Carine$$b8
000302330 7001_ $$00000-0002-6236-6804$$aZamora-Ros, Raul$$b9
000302330 7001_ $$00000-0002-9637-3869$$aHuerta, José María$$b10
000302330 7001_ $$00000-0003-4817-0757$$aSánchez, Maria-Jose$$b11
000302330 7001_ $$00000-0003-1299-6135$$aOcke, Marga$$b12
000302330 7001_ $$00000-0002-0830-5277$$aSchulze, Matthias B$$b13
000302330 7001_ $$00000-0002-9556-4540$$aSchiborn, Catarina$$b14
000302330 7001_ $$aBraaten, Tonje Bjørndal$$b15
000302330 7001_ $$00000-0003-2476-4251$$aSkeie, Guri$$b16
000302330 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b17
000302330 7001_ $$00000-0002-6396-7265$$aCastilla, Jesús$$b18
000302330 7001_ $$aKarlsson, Therese$$b19
000302330 7001_ $$00000-0002-9227-8434$$aJohansson, Ingegerd$$b20
000302330 7001_ $$00000-0002-9083-8960$$aKyrø, Cecilie$$b21
000302330 7001_ $$00000-0003-4385-2097$$aTjønneland, Anne$$b22
000302330 7001_ $$00000-0002-0284-8959$$aTong, Tammy Y N$$b23
000302330 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b24$$udkfz
000302330 7001_ $$0P:(DE-He78)0b48ce513fe49013263657450a12f870$$aBajracharya, Rashmita$$b25$$udkfz
000302330 7001_ $$00000-0003-0482-4229$$aLasheras, Cristina$$b26
000302330 7001_ $$aMidttun, Øivind$$b27
000302330 7001_ $$aVollset, Stein Emil$$b28
000302330 7001_ $$aVineis, Paolo$$b29
000302330 7001_ $$00000-0002-5758-9069$$aMasala, Giovanna$$b30
000302330 7001_ $$aAmiano, Pilar$$b31
000302330 7001_ $$00000-0003-2666-414X$$aTumino, Rosario$$b32
000302330 7001_ $$00000-0002-8537-9691$$aBaldassari, Ivan$$b33
000302330 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b34
000302330 7001_ $$aRiboli, Elio$$b35
000302330 7001_ $$aGunter, Marc J$$b36
000302330 7001_ $$aFreisling, Heinz$$b37
000302330 7001_ $$aRinaldi, Sabina$$b38
000302330 7001_ $$aMuller, David C$$b39
000302330 7001_ $$aHuybrechts, Inge$$b40
000302330 7001_ $$00000-0001-9358-7338$$aFerrari, Pietro$$b41
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