TY - JOUR AU - Park, Jin Young AU - Van Puyvelde, Heleen AU - Regazzetti, Lea AU - Clasen, Joanna L AU - Heath, Alicia K AU - Eussen, Simone AU - Ueland, Per Magne AU - Johansson, Mattias AU - Biessy, Carine AU - Zamora-Ros, Raul AU - Huerta, José María AU - Sánchez, Maria-Jose AU - Ocke, Marga AU - Schulze, Matthias B AU - Schiborn, Catarina AU - Braaten, Tonje Bjørndal AU - Skeie, Guri AU - Sacerdote, Carlotta AU - Castilla, Jesús AU - Karlsson, Therese AU - Johansson, Ingegerd AU - Kyrø, Cecilie AU - Tjønneland, Anne AU - Tong, Tammy Y N AU - Katzke, Verena AU - Bajracharya, Rashmita AU - Lasheras, Cristina AU - Midttun, Øivind AU - Vollset, Stein Emil AU - Vineis, Paolo AU - Masala, Giovanna AU - Amiano, Pilar AU - Tumino, Rosario AU - Baldassari, Ivan AU - Weiderpass, Elisabete AU - Riboli, Elio AU - Gunter, Marc J AU - Freisling, Heinz AU - Rinaldi, Sabina AU - Muller, David C AU - Huybrechts, Inge AU - Ferrari, Pietro TI - Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition. JO - Nutrients VL - 17 IS - 12 SN - 2072-6643 CY - Basel PB - MDPI M1 - DKFZ-2025-01325 SP - 1970 PY - 2025 AB - Background/Objectives: We examined the association between dietary intake and blood concentrations of one-carbon metabolism (OCM)-related nutrients in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Blood concentrations and dietary intake of the vitamins riboflavin (B2), Pyridoxal 5'-phosphate (PLP and B6), folate (B9), B12, and methionine, concentrations of homocysteine, and dietary intake of betaine, choline, and cysteine were pooled from 16,267 participants in nine EPIC nested case-control studies. Correlation analyses between dietary intakes and blood concentrations were carried out. Principal component (PC) analysis identified latent factors in the two sets of measurements. Results: Pearson correlations between dietary intakes and blood concentrations ranged from 0.08 for methionine to 0.12 for vitamin B2, 0.15 for vitamin B12, 0.17 for vitamin B6, and 0.19 for folate. Individual dietary intakes showed higher correlations (ranging from -0.14 to 0.82) compared to individual blood concentrations (from -0.31 to 0.29). Correlations did not vary by smoking status, case-control status, or vitamin supplement use. The first PC of dietary intakes was mostly associated with methionine, vitamin B12, cysteine, and choline, while the first PC of blood concentrations was associated with folate and vitamin B6. Conclusions: Within this large European study, we found weak to moderate associations between dietary intakes and concentrations of OCM-related nutrients. KW - Humans KW - Male KW - Female KW - Prospective Studies KW - Middle Aged KW - Diet KW - Europe KW - Folic Acid: blood KW - Riboflavin: blood KW - Methionine: blood KW - Vitamin B 12: blood KW - Vitamin B 6: blood KW - Case-Control Studies KW - Aged KW - Choline: blood KW - Choline: administration & dosage KW - Betaine: blood KW - Betaine: administration & dosage KW - Nutrients: blood KW - Homocysteine: blood KW - Pyridoxal Phosphate: blood KW - Carbon: metabolism KW - Neoplasms: blood KW - Nutritional Status KW - Cysteine: blood KW - Cysteine: administration & dosage KW - Adult KW - EPIC (Other) KW - blood B-vitamin concentrations (Other) KW - dietary B-vitamins (Other) KW - nutrients (Other) KW - one-carbon metabolism (Other) KW - partial least square path modeling (Other) KW - principal component analysis (Other) KW - Folic Acid (NLM Chemicals) KW - Riboflavin (NLM Chemicals) KW - Methionine (NLM Chemicals) KW - Vitamin B 12 (NLM Chemicals) KW - Vitamin B 6 (NLM Chemicals) KW - Choline (NLM Chemicals) KW - Betaine (NLM Chemicals) KW - Homocysteine (NLM Chemicals) KW - Pyridoxal Phosphate (NLM Chemicals) KW - Carbon (NLM Chemicals) KW - Cysteine (NLM Chemicals) LB - PUB:(DE-HGF)16 C6 - pmid:40573081 DO - DOI:10.3390/nu17121970 UR - https://inrepo02.dkfz.de/record/302330 ER -