TY  - JOUR
AU  - Park, Jin Young
AU  - Van Puyvelde, Heleen
AU  - Regazzetti, Lea
AU  - Clasen, Joanna L
AU  - Heath, Alicia K
AU  - Eussen, Simone
AU  - Ueland, Per Magne
AU  - Johansson, Mattias
AU  - Biessy, Carine
AU  - Zamora-Ros, Raul
AU  - Huerta, José María
AU  - Sánchez, Maria-Jose
AU  - Ocke, Marga
AU  - Schulze, Matthias B
AU  - Schiborn, Catarina
AU  - Braaten, Tonje Bjørndal
AU  - Skeie, Guri
AU  - Sacerdote, Carlotta
AU  - Castilla, Jesús
AU  - Karlsson, Therese
AU  - Johansson, Ingegerd
AU  - Kyrø, Cecilie
AU  - Tjønneland, Anne
AU  - Tong, Tammy Y N
AU  - Katzke, Verena
AU  - Bajracharya, Rashmita
AU  - Lasheras, Cristina
AU  - Midttun, Øivind
AU  - Vollset, Stein Emil
AU  - Vineis, Paolo
AU  - Masala, Giovanna
AU  - Amiano, Pilar
AU  - Tumino, Rosario
AU  - Baldassari, Ivan
AU  - Weiderpass, Elisabete
AU  - Riboli, Elio
AU  - Gunter, Marc J
AU  - Freisling, Heinz
AU  - Rinaldi, Sabina
AU  - Muller, David C
AU  - Huybrechts, Inge
AU  - Ferrari, Pietro
TI  - Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition.
JO  - Nutrients
VL  - 17
IS  - 12
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2025-01325
SP  - 1970
PY  - 2025
AB  - Background/Objectives: We examined the association between dietary intake and blood concentrations of one-carbon metabolism (OCM)-related nutrients in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Blood concentrations and dietary intake of the vitamins riboflavin (B2), Pyridoxal 5'-phosphate (PLP and B6), folate (B9), B12, and methionine, concentrations of homocysteine, and dietary intake of betaine, choline, and cysteine were pooled from 16,267 participants in nine EPIC nested case-control studies. Correlation analyses between dietary intakes and blood concentrations were carried out. Principal component (PC) analysis identified latent factors in the two sets of measurements. Results: Pearson correlations between dietary intakes and blood concentrations ranged from 0.08 for methionine to 0.12 for vitamin B2, 0.15 for vitamin B12, 0.17 for vitamin B6, and 0.19 for folate. Individual dietary intakes showed higher correlations (ranging from -0.14 to 0.82) compared to individual blood concentrations (from -0.31 to 0.29). Correlations did not vary by smoking status, case-control status, or vitamin supplement use. The first PC of dietary intakes was mostly associated with methionine, vitamin B12, cysteine, and choline, while the first PC of blood concentrations was associated with folate and vitamin B6. Conclusions: Within this large European study, we found weak to moderate associations between dietary intakes and concentrations of OCM-related nutrients.
KW  - Humans
KW  - Male
KW  - Female
KW  - Prospective Studies
KW  - Middle Aged
KW  - Diet
KW  - Europe
KW  - Folic Acid: blood
KW  - Riboflavin: blood
KW  - Methionine: blood
KW  - Vitamin B 12: blood
KW  - Vitamin B 6: blood
KW  - Case-Control Studies
KW  - Aged
KW  - Choline: blood
KW  - Choline: administration & dosage
KW  - Betaine: blood
KW  - Betaine: administration & dosage
KW  - Nutrients: blood
KW  - Homocysteine: blood
KW  - Pyridoxal Phosphate: blood
KW  - Carbon: metabolism
KW  - Neoplasms: blood
KW  - Nutritional Status
KW  - Cysteine: blood
KW  - Cysteine: administration & dosage
KW  - Adult
KW  - EPIC (Other)
KW  - blood B-vitamin concentrations (Other)
KW  - dietary B-vitamins (Other)
KW  - nutrients (Other)
KW  - one-carbon metabolism (Other)
KW  - partial least square path modeling (Other)
KW  - principal component analysis (Other)
KW  - Folic Acid (NLM Chemicals)
KW  - Riboflavin (NLM Chemicals)
KW  - Methionine (NLM Chemicals)
KW  - Vitamin B 12 (NLM Chemicals)
KW  - Vitamin B 6 (NLM Chemicals)
KW  - Choline (NLM Chemicals)
KW  - Betaine (NLM Chemicals)
KW  - Homocysteine (NLM Chemicals)
KW  - Pyridoxal Phosphate (NLM Chemicals)
KW  - Carbon (NLM Chemicals)
KW  - Cysteine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40573081
DO  - DOI:10.3390/nu17121970
UR  - https://inrepo02.dkfz.de/record/302330
ER  -