% IMPORTANT: The following is UTF-8 encoded. This means that in the presence % of non-ASCII characters, it will not work with BibTeX 0.99 or older. % Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or % “biber”. @ARTICLE{Park:302330, author = {J. Y. Park and H. Van Puyvelde and L. Regazzetti and J. L. Clasen and A. K. Heath and S. Eussen and P. M. Ueland and M. Johansson and C. Biessy and R. Zamora-Ros and J. M. Huerta and M.-J. Sánchez and M. Ocke and M. B. Schulze and C. Schiborn and T. B. Braaten and G. Skeie and C. Sacerdote and J. Castilla and T. Karlsson and I. Johansson and C. Kyrø and A. Tjønneland and T. Y. N. Tong and V. Katzke$^*$ and R. Bajracharya$^*$ and C. Lasheras and Ø. Midttun and S. E. Vollset and P. Vineis and G. Masala and P. Amiano and R. Tumino and I. Baldassari and E. Weiderpass and E. Riboli and M. J. Gunter and H. Freisling and S. Rinaldi and D. C. Muller and I. Huybrechts and P. Ferrari}, title = {{A}ssociation {B}etween {D}ietary {I}ntake and {B}lood {C}oncentrations of {O}ne-{C}arbon-{M}etabolism-{R}elated {N}utrients in {E}uropean {P}rospective {I}nvestigation into {C}ancer and {N}utrition.}, journal = {Nutrients}, volume = {17}, number = {12}, issn = {2072-6643}, address = {Basel}, publisher = {MDPI}, reportid = {DKFZ-2025-01325}, pages = {1970}, year = {2025}, abstract = {Background/Objectives: We examined the association between dietary intake and blood concentrations of one-carbon metabolism (OCM)-related nutrients in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Blood concentrations and dietary intake of the vitamins riboflavin (B2), Pyridoxal 5'-phosphate (PLP and B6), folate (B9), B12, and methionine, concentrations of homocysteine, and dietary intake of betaine, choline, and cysteine were pooled from 16,267 participants in nine EPIC nested case-control studies. Correlation analyses between dietary intakes and blood concentrations were carried out. Principal component (PC) analysis identified latent factors in the two sets of measurements. Results: Pearson correlations between dietary intakes and blood concentrations ranged from 0.08 for methionine to 0.12 for vitamin B2, 0.15 for vitamin B12, 0.17 for vitamin B6, and 0.19 for folate. Individual dietary intakes showed higher correlations (ranging from -0.14 to 0.82) compared to individual blood concentrations (from -0.31 to 0.29). Correlations did not vary by smoking status, case-control status, or vitamin supplement use. The first PC of dietary intakes was mostly associated with methionine, vitamin B12, cysteine, and choline, while the first PC of blood concentrations was associated with folate and vitamin B6. Conclusions: Within this large European study, we found weak to moderate associations between dietary intakes and concentrations of OCM-related nutrients.}, keywords = {Humans / Male / Female / Prospective Studies / Middle Aged / Diet / Europe / Folic Acid: blood / Riboflavin: blood / Methionine: blood / Vitamin B 12: blood / Vitamin B 6: blood / Case-Control Studies / Aged / Choline: blood / Choline: administration $\&$ dosage / Betaine: blood / Betaine: administration $\&$ dosage / Nutrients: blood / Homocysteine: blood / Pyridoxal Phosphate: blood / Carbon: metabolism / Neoplasms: blood / Nutritional Status / Cysteine: blood / Cysteine: administration $\&$ dosage / Adult / EPIC (Other) / blood B-vitamin concentrations (Other) / dietary B-vitamins (Other) / nutrients (Other) / one-carbon metabolism (Other) / partial least square path modeling (Other) / principal component analysis (Other) / Folic Acid (NLM Chemicals) / Riboflavin (NLM Chemicals) / Methionine (NLM Chemicals) / Vitamin B 12 (NLM Chemicals) / Vitamin B 6 (NLM Chemicals) / Choline (NLM Chemicals) / Betaine (NLM Chemicals) / Homocysteine (NLM Chemicals) / Pyridoxal Phosphate (NLM Chemicals) / Carbon (NLM Chemicals) / Cysteine (NLM Chemicals)}, cin = {C020}, ddc = {610}, cid = {I:(DE-He78)C020-20160331}, pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)}, pid = {G:(DE-HGF)POF4-313}, typ = {PUB:(DE-HGF)16}, pubmed = {pmid:40573081}, doi = {10.3390/nu17121970}, url = {https://inrepo02.dkfz.de/record/302330}, }