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@ARTICLE{Park:302330,
      author       = {J. Y. Park and H. Van Puyvelde and L. Regazzetti and J. L.
                      Clasen and A. K. Heath and S. Eussen and P. M. Ueland and M.
                      Johansson and C. Biessy and R. Zamora-Ros and J. M. Huerta
                      and M.-J. Sánchez and M. Ocke and M. B. Schulze and C.
                      Schiborn and T. B. Braaten and G. Skeie and C. Sacerdote and
                      J. Castilla and T. Karlsson and I. Johansson and C. Kyrø
                      and A. Tjønneland and T. Y. N. Tong and V. Katzke$^*$ and
                      R. Bajracharya$^*$ and C. Lasheras and Ø. Midttun and S. E.
                      Vollset and P. Vineis and G. Masala and P. Amiano and R.
                      Tumino and I. Baldassari and E. Weiderpass and E. Riboli and
                      M. J. Gunter and H. Freisling and S. Rinaldi and D. C.
                      Muller and I. Huybrechts and P. Ferrari},
      title        = {{A}ssociation {B}etween {D}ietary {I}ntake and {B}lood
                      {C}oncentrations of {O}ne-{C}arbon-{M}etabolism-{R}elated
                      {N}utrients in {E}uropean {P}rospective {I}nvestigation into
                      {C}ancer and {N}utrition.},
      journal      = {Nutrients},
      volume       = {17},
      number       = {12},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2025-01325},
      pages        = {1970},
      year         = {2025},
      abstract     = {Background/Objectives: We examined the association between
                      dietary intake and blood concentrations of one-carbon
                      metabolism (OCM)-related nutrients in the European
                      Prospective Investigation into Cancer and Nutrition (EPIC).
                      Methods: Blood concentrations and dietary intake of the
                      vitamins riboflavin (B2), Pyridoxal 5'-phosphate (PLP and
                      B6), folate (B9), B12, and methionine, concentrations of
                      homocysteine, and dietary intake of betaine, choline, and
                      cysteine were pooled from 16,267 participants in nine EPIC
                      nested case-control studies. Correlation analyses between
                      dietary intakes and blood concentrations were carried out.
                      Principal component (PC) analysis identified latent factors
                      in the two sets of measurements. Results: Pearson
                      correlations between dietary intakes and blood
                      concentrations ranged from 0.08 for methionine to 0.12 for
                      vitamin B2, 0.15 for vitamin B12, 0.17 for vitamin B6, and
                      0.19 for folate. Individual dietary intakes showed higher
                      correlations (ranging from -0.14 to 0.82) compared to
                      individual blood concentrations (from -0.31 to 0.29).
                      Correlations did not vary by smoking status, case-control
                      status, or vitamin supplement use. The first PC of dietary
                      intakes was mostly associated with methionine, vitamin B12,
                      cysteine, and choline, while the first PC of blood
                      concentrations was associated with folate and vitamin B6.
                      Conclusions: Within this large European study, we found weak
                      to moderate associations between dietary intakes and
                      concentrations of OCM-related nutrients.},
      keywords     = {Humans / Male / Female / Prospective Studies / Middle Aged
                      / Diet / Europe / Folic Acid: blood / Riboflavin: blood /
                      Methionine: blood / Vitamin B 12: blood / Vitamin B 6: blood
                      / Case-Control Studies / Aged / Choline: blood / Choline:
                      administration $\&$ dosage / Betaine: blood / Betaine:
                      administration $\&$ dosage / Nutrients: blood /
                      Homocysteine: blood / Pyridoxal Phosphate: blood / Carbon:
                      metabolism / Neoplasms: blood / Nutritional Status /
                      Cysteine: blood / Cysteine: administration $\&$ dosage /
                      Adult / EPIC (Other) / blood B-vitamin concentrations
                      (Other) / dietary B-vitamins (Other) / nutrients (Other) /
                      one-carbon metabolism (Other) / partial least square path
                      modeling (Other) / principal component analysis (Other) /
                      Folic Acid (NLM Chemicals) / Riboflavin (NLM Chemicals) /
                      Methionine (NLM Chemicals) / Vitamin B 12 (NLM Chemicals) /
                      Vitamin B 6 (NLM Chemicals) / Choline (NLM Chemicals) /
                      Betaine (NLM Chemicals) / Homocysteine (NLM Chemicals) /
                      Pyridoxal Phosphate (NLM Chemicals) / Carbon (NLM Chemicals)
                      / Cysteine (NLM Chemicals)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40573081},
      doi          = {10.3390/nu17121970},
      url          = {https://inrepo02.dkfz.de/record/302330},
}