Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition.

Park, Jin Young; Vollset, Stein Emil; Heath, Alicia K; Tumino, Rosario; Sacerdote, Carlotta; Ferrari, Pietro; Amiano, Pilar; Ocke, Marga; Tong, Tammy Y N; Zamora-Ros, Raul; Braaten, Tonje Bjørndal; Bajracharya, Rashmita; Eussen, Simone; Karlsson, Therese; Tjønneland, Anne; Biessy, Carine; Lasheras, Cristina; Regazzetti, Lea; Schiborn, Catarina; Rinaldi, Sabina; Sánchez, Maria-Jose; Masala, Giovanna; Midttun, Øivind; Baldassari, Ivan; Huybrechts, Inge; Riboli, Elio; Clasen, Joanna L; Gunter, Marc J; Johansson, Ingegerd; Van Puyvelde, Heleen; Castilla, Jesús; Skeie, Guri; Katzke, Verena; Muller, David C; Freisling, Heinz; Johansson, Mattias; Kyrø, Cecilie; Vineis, Paolo; Huerta, José María; Weiderpass, Elisabete; Schulze, Matthias B; Ueland, Per Magne

doi:10.3390/nu17121970

Items
Marc 21

001			302330
005			20250630113839.0
024	7	_	\|a 10.3390/nu17121970 \|2 doi
024	7	_	\|a pmid:40573081 \|2 pmid
037	_	_	\|a DKFZ-2025-01325
041	_	_	\|a English
082	_	_	\|a 610
100	1	_	\|a Park, Jin Young \|0 0000-0003-2491-5099 \|b 0
245	_	_	\|a Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition.
260	_	_	\|a Basel \|c 2025 \|b MDPI
336	7	_	\|a article \|2 DRIVER
336	7	_	\|a Output Types/Journal article \|2 DataCite
336	7	_	\|a Journal Article \|b journal \|m journal \|0 PUB:(DE-HGF)16 \|s 1751273292_21722 \|2 PUB:(DE-HGF)
336	7	_	\|a ARTICLE \|2 BibTeX
336	7	_	\|a JOURNAL_ARTICLE \|2 ORCID
336	7	_	\|a Journal Article \|0 0 \|2 EndNote
520	_	_	\|a Background/Objectives: We examined the association between dietary intake and blood concentrations of one-carbon metabolism (OCM)-related nutrients in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Blood concentrations and dietary intake of the vitamins riboflavin (B2), Pyridoxal 5'-phosphate (PLP and B6), folate (B9), B12, and methionine, concentrations of homocysteine, and dietary intake of betaine, choline, and cysteine were pooled from 16,267 participants in nine EPIC nested case-control studies. Correlation analyses between dietary intakes and blood concentrations were carried out. Principal component (PC) analysis identified latent factors in the two sets of measurements. Results: Pearson correlations between dietary intakes and blood concentrations ranged from 0.08 for methionine to 0.12 for vitamin B2, 0.15 for vitamin B12, 0.17 for vitamin B6, and 0.19 for folate. Individual dietary intakes showed higher correlations (ranging from -0.14 to 0.82) compared to individual blood concentrations (from -0.31 to 0.29). Correlations did not vary by smoking status, case-control status, or vitamin supplement use. The first PC of dietary intakes was mostly associated with methionine, vitamin B12, cysteine, and choline, while the first PC of blood concentrations was associated with folate and vitamin B6. Conclusions: Within this large European study, we found weak to moderate associations between dietary intakes and concentrations of OCM-related nutrients.
536	_	_	\|a 313 - Krebsrisikofaktoren und Prävention (POF4-313) \|0 G:(DE-HGF)POF4-313 \|c POF4-313 \|f POF IV \|x 0
588	_	_	\|a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
650	_	7	\|a EPIC \|2 Other
650	_	7	\|a blood B-vitamin concentrations \|2 Other
650	_	7	\|a dietary B-vitamins \|2 Other
650	_	7	\|a nutrients \|2 Other
650	_	7	\|a one-carbon metabolism \|2 Other
650	_	7	\|a partial least square path modeling \|2 Other
650	_	7	\|a principal component analysis \|2 Other
650	_	7	\|a Folic Acid \|0 935E97BOY8 \|2 NLM Chemicals
650	_	7	\|a Riboflavin \|0 TLM2976OFR \|2 NLM Chemicals
650	_	7	\|a Methionine \|0 AE28F7PNPL \|2 NLM Chemicals
650	_	7	\|a Vitamin B 12 \|0 P6YC3EG204 \|2 NLM Chemicals
650	_	7	\|a Vitamin B 6 \|0 8059-24-3 \|2 NLM Chemicals
650	_	7	\|a Choline \|0 N91BDP6H0X \|2 NLM Chemicals
650	_	7	\|a Betaine \|0 3SCV180C9W \|2 NLM Chemicals
650	_	7	\|a Homocysteine \|0 0LVT1QZ0BA \|2 NLM Chemicals
650	_	7	\|a Pyridoxal Phosphate \|0 5V5IOJ8338 \|2 NLM Chemicals
650	_	7	\|a Carbon \|0 7440-44-0 \|2 NLM Chemicals
650	_	7	\|a Cysteine \|0 K848JZ4886 \|2 NLM Chemicals
650	_	2	\|a Humans \|2 MeSH
650	_	2	\|a Male \|2 MeSH
650	_	2	\|a Female \|2 MeSH
650	_	2	\|a Prospective Studies \|2 MeSH
650	_	2	\|a Middle Aged \|2 MeSH
650	_	2	\|a Diet \|2 MeSH
650	_	2	\|a Europe \|2 MeSH
650	_	2	\|a Folic Acid: blood \|2 MeSH
650	_	2	\|a Riboflavin: blood \|2 MeSH
650	_	2	\|a Methionine: blood \|2 MeSH
650	_	2	\|a Vitamin B 12: blood \|2 MeSH
650	_	2	\|a Vitamin B 6: blood \|2 MeSH
650	_	2	\|a Case-Control Studies \|2 MeSH
650	_	2	\|a Aged \|2 MeSH
650	_	2	\|a Choline: blood \|2 MeSH
650	_	2	\|a Choline: administration & dosage \|2 MeSH
650	_	2	\|a Betaine: blood \|2 MeSH
650	_	2	\|a Betaine: administration & dosage \|2 MeSH
650	_	2	\|a Nutrients: blood \|2 MeSH
650	_	2	\|a Homocysteine: blood \|2 MeSH
650	_	2	\|a Pyridoxal Phosphate: blood \|2 MeSH
650	_	2	\|a Carbon: metabolism \|2 MeSH
650	_	2	\|a Neoplasms: blood \|2 MeSH
650	_	2	\|a Nutritional Status \|2 MeSH
650	_	2	\|a Cysteine: blood \|2 MeSH
650	_	2	\|a Cysteine: administration & dosage \|2 MeSH
650	_	2	\|a Adult \|2 MeSH
700	1	_	\|a Van Puyvelde, Heleen \|b 1
700	1	_	\|a Regazzetti, Lea \|b 2
700	1	_	\|a Clasen, Joanna L \|0 0000-0003-4231-5740 \|b 3
700	1	_	\|a Heath, Alicia K \|0 0000-0001-6517-1300 \|b 4
700	1	_	\|a Eussen, Simone \|0 0000-0003-0559-6838 \|b 5
700	1	_	\|a Ueland, Per Magne \|b 6
700	1	_	\|a Johansson, Mattias \|b 7
700	1	_	\|a Biessy, Carine \|b 8
700	1	_	\|a Zamora-Ros, Raul \|0 0000-0002-6236-6804 \|b 9
700	1	_	\|a Huerta, José María \|0 0000-0002-9637-3869 \|b 10
700	1	_	\|a Sánchez, Maria-Jose \|0 0000-0003-4817-0757 \|b 11
700	1	_	\|a Ocke, Marga \|0 0000-0003-1299-6135 \|b 12
700	1	_	\|a Schulze, Matthias B \|0 0000-0002-0830-5277 \|b 13
700	1	_	\|a Schiborn, Catarina \|0 0000-0002-9556-4540 \|b 14
700	1	_	\|a Braaten, Tonje Bjørndal \|b 15
700	1	_	\|a Skeie, Guri \|0 0000-0003-2476-4251 \|b 16
700	1	_	\|a Sacerdote, Carlotta \|0 0000-0002-8008-5096 \|b 17
700	1	_	\|a Castilla, Jesús \|0 0000-0002-6396-7265 \|b 18
700	1	_	\|a Karlsson, Therese \|b 19
700	1	_	\|a Johansson, Ingegerd \|0 0000-0002-9227-8434 \|b 20
700	1	_	\|a Kyrø, Cecilie \|0 0000-0002-9083-8960 \|b 21
700	1	_	\|a Tjønneland, Anne \|0 0000-0003-4385-2097 \|b 22
700	1	_	\|a Tong, Tammy Y N \|0 0000-0002-0284-8959 \|b 23
700	1	_	\|a Katzke, Verena \|0 P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4 \|b 24 \|u dkfz
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700	1	_	\|a Lasheras, Cristina \|0 0000-0003-0482-4229 \|b 26
700	1	_	\|a Midttun, Øivind \|b 27
700	1	_	\|a Vollset, Stein Emil \|b 28
700	1	_	\|a Vineis, Paolo \|b 29
700	1	_	\|a Masala, Giovanna \|0 0000-0002-5758-9069 \|b 30
700	1	_	\|a Amiano, Pilar \|b 31
700	1	_	\|a Tumino, Rosario \|0 0000-0003-2666-414X \|b 32
700	1	_	\|a Baldassari, Ivan \|0 0000-0002-8537-9691 \|b 33
700	1	_	\|a Weiderpass, Elisabete \|0 0000-0003-2237-0128 \|b 34
700	1	_	\|a Riboli, Elio \|b 35
700	1	_	\|a Gunter, Marc J \|b 36
700	1	_	\|a Freisling, Heinz \|b 37
700	1	_	\|a Rinaldi, Sabina \|b 38
700	1	_	\|a Muller, David C \|b 39
700	1	_	\|a Huybrechts, Inge \|b 40
700	1	_	\|a Ferrari, Pietro \|0 0000-0001-9358-7338 \|b 41
773	_	_	\|a 10.3390/nu17121970 \|g Vol. 17, no. 12, p. 1970 - \|0 PERI:(DE-600)2518386-2 \|n 12 \|p 1970 \|t Nutrients \|v 17 \|y 2025 \|x 2072-6643
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Marc 21

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