% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Toberer:302799,
      author       = {F. Toberer and J. K. Winkler and L. Atienza Fernandez$^*$
                      and L. Adams$^*$ and A. Brobeil and M. Tóth and A. H. Enk
                      and J. Becker$^*$ and A. Lonsdorf},
      title        = {{I}nhibitory {I}mmune {C}heckpoints beyond {P}rogrammed
                      {C}ell {D}eath {L}igand 1 in {M}erkel {C}ell {C}arcinoma:
                      {A}bundant {E}xpression of {TIGIT} {I}ndependent of the
                      {P}resence of {M}erkel {C}ell {P}olyoma {V}irus.},
      journal      = {Acta dermato-venereologica},
      volume       = {105},
      issn         = {0001-5555},
      address      = {Uppsala},
      publisher    = {Acta Dermato-Venereologica},
      reportid     = {DKFZ-2025-01339},
      pages        = {adv42882},
      year         = {2025},
      note         = {DKFZ-ZMBH Alliance},
      abstract     = {Merkel cell carcinoma is a rare, aggressive skin cancer in
                      which Merkel cell polyoma virus (MCPyV) is frequently
                      pathogenically involved. After failure of anti-programmed
                      cell death protein 1/programmed cell death ligand 1
                      immunotherapy, therapeutic options for advanced disease are
                      limited. The contribution of the coinhibitory checkpoint
                      molecule T cell immunoreceptor with immunoglobulin and
                      immunoreceptor tyrosine-based inhibitory motif domain
                      (TIGIT), a regulator of exhausted CD8+ T cells, to the
                      immunosuppressive Merkel cell carcinoma microenvironment is
                      understudied. This study evaluated the immunohistochemical
                      expression of tumour (Tumor Proportion Score, TPS) and
                      infiltrating immune cells (Immune Cell Score, ICS) for
                      programmed cell death ligand 1, TIGIT, its high-affinity
                      receptor CD155, and CD8 in 21 primary Merkel cell carcinoma
                      and 6 metastases. Unlike CD155, TIGIT was abundantly
                      expressed by tumour and immune cells and independent of the
                      MCPyV status, determined by RT-PCR. Programmed cell death
                      ligand 1+ immune cells were significantly increased in TIGIT
                      TPS-positive and MCPyV-positive primary MCC along with
                      significant intercorrelations of programmed cell death
                      ligand 1 and TIGIT immune cell expression and CD8+
                      infiltrates. Programmed cell death ligand 1 IC-positivity
                      correlated with superior disease-specific survival. The data
                      indicate that TIGIT may contribute to local immune
                      dysfunction in Merkel cell carcinoma, beyond programmed cell
                      death ligand 1 and independent of MCPyV, and provide a
                      rationale to further explore TIGIT as a potential target for
                      Merkel cell carcinoma immunotherapy.},
      keywords     = {Humans / Carcinoma, Merkel Cell: immunology / Carcinoma,
                      Merkel Cell: virology / Carcinoma, Merkel Cell: secondary /
                      Carcinoma, Merkel Cell: mortality / Carcinoma, Merkel Cell:
                      pathology / Receptors, Immunologic: analysis / Receptors,
                      Immunologic: genetics / Receptors, Immunologic: metabolism /
                      Skin Neoplasms: immunology / Skin Neoplasms: virology / Skin
                      Neoplasms: pathology / Skin Neoplasms: mortality / Male /
                      Merkel cell polyomavirus: immunology / Merkel cell
                      polyomavirus: isolation $\&$ purification / Female / Aged /
                      B7-H1 Antigen: analysis / B7-H1 Antigen: metabolism /
                      Polyomavirus Infections: immunology / Polyomavirus
                      Infections: virology / Middle Aged / Aged, 80 and over /
                      Tumor Microenvironment / Tumor Virus Infections: immunology
                      / Tumor Virus Infections: virology / Lymphocytes,
                      Tumor-Infiltrating: immunology / Biomarkers, Tumor: analysis
                      / Biomarkers, Tumor: genetics / CD8-Positive T-Lymphocytes:
                      immunology / Receptors, Virus: analysis / TIGIT protein,
                      human (NLM Chemicals) / Receptors, Immunologic (NLM
                      Chemicals) / B7-H1 Antigen (NLM Chemicals) / CD274 protein,
                      human (NLM Chemicals) / poliovirus receptor (NLM Chemicals)
                      / Biomarkers, Tumor (NLM Chemicals) / Receptors, Virus (NLM
                      Chemicals)},
      cin          = {ED01 / A130},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331 / I:(DE-He78)A130-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40590417},
      pmc          = {pmc:PMC12235568},
      doi          = {10.2340/actadv.v105.42882},
      url          = {https://inrepo02.dkfz.de/record/302799},
}